Strengthening of national capacity in implementation of antimalarial drug quality assurance in Thailand.

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dc.contributor.authorVijaykadga, Saowaniten_US
dc.contributor.authorCholpol, Sawaten_US
dc.contributor.authorSitthimongkol, Saipinen_US
dc.contributor.authorPawaphutanan, Anusornen_US
dc.contributor.authorPinyoratanachot, Arunyaen_US
dc.contributor.authorRojanawatsirivet, Chaipornen_US
dc.contributor.authorKovithvattanapong, Rojanaen_US
dc.contributor.authorThimasarn, Krongthongen_US
dc.date.accessioned2009-05-27T16:05:36Z
dc.date.available2009-05-27T16:05:36Z
dc.date.issued2006-05-06en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractSubstandard and counterfeit pharmaceutical products, including antimalarial drugs, appear to be widespread internationally and affect both the developing and developed countries. The aim of the study was to investigate the quality of antimalarial drugs, ie, artesunate (ART), chloroquine (CHL), mefloquine (MEF), quinine (QUI), sulfadoxine/pyrimethamine (S/P) and tetracycline (TT) obtained from the government sector and private pharmacies in 4 Thai provinces: Mae Hong Son, Kanchanaburi, Ranong, and Chanthaburi. Three hundred sixty-nine samples of 6 antimalarial drugs from 27 government hospitals, 27 malaria clinics, and 53 drugstores, were collected. Drug quality was assessed by simple disintegration test and semi-quantitative thin-layer chromatography in each province; 10% passed, 100% failed and doubtful samples were sent to be verified by high performance liquid chromatography (HPLC) at the Thai National Drug Analysis Laboratory, (NL). Fifteen point four percent of ART, 11.1% of CHL and 29.4% of QUI were substandard. Based on the finding, drug regulatory authorities in the country took appropriate action against violators to ensure that antimalarial drugs consumed by malaria patients are of good quality.en_US
dc.description.affiliationDepartment of Disease Control, Ministry of Public Health, Thailand. saowanit@health.moph.go.then_US
dc.identifier.citationVijaykadga S, Cholpol S, Sitthimongkol S, Pawaphutanan A, Pinyoratanachot A, Rojanawatsirivet C, Kovithvattanapong R, Thimasarn K. Strengthening of national capacity in implementation of antimalarial drug quality assurance in Thailand. The Southeast Asian Journal of Tropical Medicine and Public Health. 2006 ; 37 Suppl 3(): 5-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34399
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2006_37_spp3/37sup3_5.pdfen_US
dc.subject.meshAntimalarials --standardsen_US
dc.subject.meshFrauden_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria --drug therapyen_US
dc.subject.meshProduct Surveillance, Postmarketingen_US
dc.subject.meshQuality Controlen_US
dc.subject.meshSafetyen_US
dc.subject.meshThailanden_US
dc.titleStrengthening of national capacity in implementation of antimalarial drug quality assurance in Thailand.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
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