Effects of cow ghee (clarified butter oil) & soybean oil on carcinogen-metabolizing enzymes in rats.

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dc.contributor.authorRani, Rita
dc.contributor.authorKansal, Vinod K
dc.date.accessioned2013-01-29T04:58:30Z
dc.date.available2013-01-29T04:58:30Z
dc.date.issued2012-09
dc.description.abstractBackground & objectives: Our previous study showed that cow ghee relative to soybean oil had a protective effect against carcinogen induced mammary cancer in rats. The objective of this study was to elucidate its biochemical mechanism. Methods: Two groups of 21 day old rats (20 each) were fed for 44 wk diet containing cow ghee or soybean oil (10%). Five animals from each group were sacrificed at 0 day and at 5, 21 and 44 wk for analysis of phase I and phase II pathways enzymes of carcinogen metabolism. Results: Dietary cow ghee relative to soybean oil decreased the activities of cytochrome P450 (CYP) enzymes, CYP1A1, CYP1A2, CYP1B1 and CYP2B1, responsible for activation of carcinogen in liver. Carcinogen detoxification activities of uridinediphospho-glucuronosyl transferase (UDPGT) and quinone reductase (QR) in liver, and γ-glutamyltranspeptidase (GGTP) and QR in mammary tissue were significantly higher in cow ghee fed rats than in soybean oil fed rats. The hepatic GGTP activity decreased on soybean oil diet; while in cow ghee group it remained unaffected. Interpretation & conclusions: Our findings show that dietary cow ghee compared to soybean oil downregulates the enzyme activities responsible for carcinogen activation in liver and upregulates carcinogen detoxification activities in liver and mammary tissues.en_US
dc.identifier.citationRani Rita, Kansal Vinod K. Effects of cow ghee (clarified butter oil) & soybean oil on carcinogen-metabolizing enzymes in rats. Indian Journal of Medical Research. 2012 Sept; 136(3): 460-465.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144769
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510893/en_US
dc.subjectCarcinogen detoxification enzymesen_US
dc.subjectcow gheeen_US
dc.subjectcytochrome P450 enzymesen_US
dc.subjectsoybean oilen_US
dc.subject.meshAnimals
dc.subject.meshCytochrome P-450 Enzyme System --analysis
dc.subject.meshCytochrome P-450 Enzyme System --metabolism
dc.subject.meshCytochrome P-450 Enzyme System --physiology
dc.subject.meshDietary Fats --administration & dosage
dc.subject.meshDietary Fats --physiology
dc.subject.meshDisease Models, Animal
dc.subject.meshRats
dc.subject.meshSoybean Oil --administration & dosage
dc.subject.meshSoybean Oil --physiology
dc.titleEffects of cow ghee (clarified butter oil) & soybean oil on carcinogen-metabolizing enzymes in rats.en_US
dc.typeArticleen_US
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