A review on phyto-nanotechnology for therapy of alzheimer’s disease

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dc.contributor.authorR, Gayathrien_US
dc.contributor.authorSL, Manjuen_US
dc.date.accessioned2023-08-09T06:02:01Z
dc.date.available2023-08-09T06:02:01Z
dc.date.issued2022-09
dc.description.abstractAlzheimer’s disease (AD) is a common chronic neurodegenerative disease (ND) that is mainly investigated nowadays because of its increased incidence and burden on the elderly population. It leads to atrophy of the brain. Clinical features of AD include loss of memory with impaired cognition and behaviour, which leads to mood instability and death. Aggregation of beta-amyloid protein(A?) and neurofibrillary tangles within the neuronal cells are the accepted pathophysiological process of AD. Studies have demonstrated that medicinal plants and herbs could improve memory and cognitive function affected by AD. The bioavailability of active herbal components is affected by rapid metabolism, less permeability, and decreased stability within the CNS. Many studies have reported that the application of nanotechnology to plant extracts enhances the efficacy of extracts. Adding herbal extracts into the nanoparticle system could improve the action of extracts, promote the sustained release of bioactive components, decrease the required dose, and lower the side effects. Using published articles from trustworthy resources like PubMed, Google Scholar, Research Gate, Web of Science, and Wiley Online Library, with keywords like "natural products," "Alzheimer's disease," and "nanotechnology," herein we reviewed and summarized recent nano-drug delivery treatment strategies for AD using natural products.en_US
dc.identifier.affiliationsSchool of advanced sciences, VIT, Vellore-632 014, Tamil Nadu, Indiaen_US
dc.identifier.citationR Gayathri, SL Manju. A review on phyto-nanotechnology for therapy of alzheimer’s disease. Indian Journal of Biochemistry & Biophysics. 2022 Sept; 59(9): 867-872en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221568
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber9en_US
dc.relation.volume59en_US
dc.source.urihttps://doi.org/10.56042/ijbb.v59i9.57758en_US
dc.subjectAmyloid plaqueen_US
dc.subjectBlood-brain barrieren_US
dc.subjectCNSen_US
dc.subjectNanotechnologyen_US
dc.subjectNatural productsen_US
dc.titleA review on phyto-nanotechnology for therapy of alzheimer’s diseaseen_US
dc.typeJournal Articleen_US
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