Neutrophil-Lymphocyte Ratio for Predicting Coronary Artery Lesions in Children With Kawasaki Disease

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dc.contributor.authorChidambaram, Aakash Chandranen_US
dc.contributor.authorRamamoorthy, Jaikumar Govindaswamyen_US
dc.contributor.authorAnantharaj, Avinashen_US
dc.date.accessioned2023-08-25T06:39:56Z
dc.date.available2023-08-25T06:39:56Z
dc.date.issued2023-03
dc.description.abstractBackground: Coronary artery lesions (CAL) are a specific feature of Kawasaki disease (KD), and develop during the second week of illness. This study was conducted to determine whether Neutrophil: Lymphocyte Ratio (NLR), assessed between the fourth and sixth day of fever onset in children with KD, can predict coronary artery lesion (CAL) development. Methods: In this review of hospital records, data of patients with KD admitted at our center between January, 2016 and January, 2020 was retrieved. The patients were divided into two groups based on the presence of CAL, and clinical characteristics of patients were compared between the two groups. Results: Out of the 79 patients enrolled, CAL was found in 40 (50.6%) patients and intravenous immunoglobulin (IVIg) resistance was seen in 13 (16.5%) patients. Multivariate logistic regression revealed NLR as an independent predictor of CAL [OR (95% CI) 2.0 (1.2-3.1); P<0.001], and erythrocyte sedimentation rate (ESR) [OR (95% CI) 1.03 (1.001-1.1) P=0.04], as an independent predictor of IVIg resistance. NLR ?2.08 was 82% sensitive and 80% specific in predicting CAL. ESR ?88 mm/h was 85% sensitive and 64% specific in predicting IVIg resistance. Conclusions: NLR is an independent predictor of CAL in KD. NLR ?2.08 done between the fourth and sixth day of fever onset may identify children with KD at risk of CAL.en_US
dc.identifier.affiliationsDepartments of Pediatricsen_US
dc.identifier.affiliationsCardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry.en_US
dc.identifier.citationChidambaram Aakash Chandran, Ramamoorthy Jaikumar Govindaswamy, Anantharaj Avinash. Neutrophil-Lymphocyte Ratio for Predicting Coronary Artery Lesions in Children With Kawasaki Disease. Indian Pediatrics. 2023 Mar; 60(3): 207-211en_US
dc.identifier.issn0079-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225396
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber3en_US
dc.relation.volume60en_US
dc.source.urihttps://indianpediatrics.net/mar2023/207.pdfen_US
dc.subjectAneurysmen_US
dc.subjectErythrocyte sedimentation rateen_US
dc.subjectIntravenous immunoglobulin resistanceen_US
dc.subjectPrognosis.en_US
dc.titleNeutrophil-Lymphocyte Ratio for Predicting Coronary Artery Lesions in Children With Kawasaki Diseaseen_US
dc.typeJournal Articleen_US
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