CD3+, CD4+ & CD8+ tumour infiltrating lymphocytes (TILs) are predictors of favourable survival outcome in infiltrating ductal carcinoma of breast.

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dc.contributor.authorRathore, Ankita Singh
dc.contributor.authorKumar, Sandeep
dc.contributor.authorKonwar, Rituraj
dc.contributor.authorMakker, Annu
dc.contributor.authorNegi, M P S
dc.contributor.authorGoel, Madhu Mati
dc.date.accessioned2015-01-21T09:24:04Z
dc.date.available2015-01-21T09:24:04Z
dc.date.issued2014-09
dc.description.abstractBackground & objectives: Tumour infiltrating lymphocytes (TILs) represent the host immune response against cancer cells associated with good or bad prognosis in different tumour types. This study was undertaken to evaluate the significance of CD3+, CD4+ and CD8+ TILs in breast cancer tissues in relation to clinico-pathological variables and survival outcome. Methods: Immunohistochemistry (IHC) was performed with antibodies against CD3, CD4 and CD8 antigens on formalin-fixed paraffin-embedded tissue sections of 150 breast cancer patients. Intratumoural and stromal TIL counting was performed semiquantitatively. Results: The higher CD3+, CD4+ and CD8+ intratumoural and stromal counts showed independent and direct association with good prognosis. The prognostic predictor value of intratumoural counts was higher than stromal counts. The independent associations of intratumoural and stromal counts became more prominent when adjusted with stage and grade, respectively. Among intratumoural counts, the high (++/+++) CD4+ count (OR=3.85, 95% CI=3.28-16.71, P<0.001) showed the highest survival followed by CD3+ (OR=2.70, 95% CI=1.76-8.30, P=0.001) and CD8+ (OR=2.58, 95% CI=1.55-5.86, pP=0.001) the least when compared to respective low (+) counts. In contrast, among stromal counts, the high CD8+ count (OR=3.13, 95% CI=2.20-9.57, pP<0.001) showed the highest survival followed by CD4+ (OR=3.02, 95% CI=2.07-8.89, 0.001) and CD3+ (OR=2.45, 95% CI=1.53-6.73, 0.002) the least. Interpretation & conclusions: Our results suggest that intratumoural CD4+ and stromal CD8+ counts by immunohistochemistry may serve as an independent prognosticator for favourable outcome in breast cancer.en_US
dc.identifier.citationRathore Ankita Singh, Kumar Sandeep, Konwar Rituraj, Makker Annu, Negi M P S, Goel Madhu Mati. CD3+, CD4+ & CD8+ tumour infiltrating lymphocytes (TILs) are predictors of favourable survival outcome in infiltrating ductal carcinoma of breast. Indian Journal of Medical Research. 2014 Sep;140 (3): 361-369.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/155378
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248382/en_US
dc.subjectBreast canceren_US
dc.subjectCD3en_US
dc.subjectCD4en_US
dc.subjectCD8en_US
dc.subjectductal carcinomaen_US
dc.subjecttumour infiltrating lymphocytesen_US
dc.titleCD3+, CD4+ & CD8+ tumour infiltrating lymphocytes (TILs) are predictors of favourable survival outcome in infiltrating ductal carcinoma of breast.en_US
dc.typeArticleen_US
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