Vitamin D and Diabetes: A New Horizon.
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Date
2014-07
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Abstract
Diabetes mellitus is a metabolic disease which is caused by absolute or relative insulin deficiency, and the prevalence rate of Type2 diabetes
mellitus (T2DM) is growing among Indians as well as through worldwide. Various risk factors play a role in the aetiopathogenesis and
in the glycemic control among the type 2 diabetic patients. Therefore, identification of environmental and easily modified risk factors is
urgently needed to prevent development of T2DM. One of various such risk factors, vitamin D3 level & therefore serum calcium levels
are reported to alter the glycemic control. The major and most well-known function of vitamin D is to maintain calcium and phosphorus
homeostasis and promote bone mineralization. However, recent evidence suggests that vitamin D and calcium homeostasis may also
be important for a variety of non-skeletal diseases including T2DM. Based on basic and animal studies, vitamin D and calcium have
also been suspected as modifiers of diabetes risk. The systemic review was carried out to evaluate the evidences as well as limitation in
respect of vitamin D3 and serum calcium level regarding the glycemic control in T2DM. This paper seeks to examine the consistently
reported relationship between glycemic control in T2DM and altered vitamin D3 & serum calcium concentrations, with reference to
the possible underlying mechanisms. So the status of above two parameters is considered as an important factor in T2DM patients.
Its role in present scenario should be understood both as an etiological concept & also as a therapeutic option.
Description
Keywords
Vitamin D,, Diabetes, Glycemic parameter
Citation
Amit Varma, Vandana Koranga, Kumar Neeraj, Kothiyal Preeti. Vitamin D and Diabetes: A New Horizon. Acta Medica International. 2014 Jul-Dec; 1(2): 134-139.