Theophylline clearance in undernourished asthma patients.

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dc.contributor.authorRaj, N Sen_US
dc.contributor.authorMisra, Aen_US
dc.contributor.authorGuleria, Ren_US
dc.contributor.authorPande, J Nen_US
dc.date.accessioned1998-07-27en_US
dc.date.accessioned2009-05-27T10:11:05Z
dc.date.available1998-07-27en_US
dc.date.available2009-05-27T10:11:05Z
dc.date.issued1998-07-27en_US
dc.description.abstractTheophylline clearance is altered by many drugs and diseases that may be associated with undernutrition. Therefore, we studied theophylline clearance in 12 undernourished [body mass index (BMI) less than 19] and 12 well nourished asthma patients (body mass index more than 19). Uncoated theophylline tablet (200 mg, 300 mg dose 5 mg/kg approx) was administered orally to each asthma patient after 12 hours overnight fasting. Serum theophylline concentrations were estimated after 2, 4, 6, 8 hours of drug administration and it was calculated from log conc: time curve. Undernourished asthma patients had a mean theophylline clearance of 85.6 (SE = 6.2) ml/hr/kg while it was 125.6 (SE = 3.8) ml/hr/kg in well-nourished asthma patients. The difference between two groups was highly significant (p < 0.01). We conclude that theophylline clearance is significantly lower in undernourished asthma patients and they will require a lower maintenance dose of theophylline.en_US
dc.description.affiliationSRB Centre for Clinical Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi. nsraj@medinst.ernet.inen_US
dc.identifier.citationRaj NS, Misra A, Guleria R, Pande JN. Theophylline clearance in undernourished asthma patients. The Indian Journal of Chest Diseases & Allied Sciences. 1998 Jul-Sep; 40(3): 175-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/29301
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/iae/iaem.shtmlen_US
dc.subject.meshAdulten_US
dc.subject.meshAsthma --complicationsen_US
dc.subject.meshBronchodilator Agents --administration & dosageen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNutrition Disorders --complicationsen_US
dc.subject.meshNutritional Statusen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshTheophylline --administration & dosageen_US
dc.titleTheophylline clearance in undernourished asthma patients.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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