Complicated malaria is associated with differential elevations in serum levels of interleukins 10, 12, and 15.

Simple item page
dc.contributor.authorGosi, Pen_US
dc.contributor.authorKhusmith, Sen_US
dc.contributor.authorLooareesuwan, Sen_US
dc.contributor.authorSitachamroom, Uen_US
dc.contributor.authorGlanarongran, Ren_US
dc.contributor.authorBuchachart, Ken_US
dc.contributor.authorWalsh, D Sen_US
dc.date.accessioned2009-05-27T16:13:11Z
dc.date.available2009-05-27T16:13:11Z
dc.date.issued1999-09-25en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractComplicated malaria, caused by Plasmodium falciparum, is characterized by multiple organ dysfunction. The pathogenesis of complicated malaria involves complex host-parasite interactions that include polarized cytokine responses. Recently, correlates between Th1-like and Th2-like cytokines, especially interleukin-10 (IL), IL-12, and TNF-alpha, and specific types of organ dysfunction have been noted. Here, we measured IL-10, IL-12, and for the first time, IL-15, in 19 patients aged 16-55 years old with complicated malaria on days 0 (admission), 3, 7, and 14. For analysis, patients were grouped together or sub-categorized into hyperparasitemias or cerebral malaria (CM). For IL-10, a dramatic increase was noted on admission, followed by a reduction toward control values that closely paralleled parasite clearance. For IL-12, modest but persistent increases were noted over the entire 14 day period that did not correlate with parasitemia. In general, especially on days 0 and 3, hyperparasitemic patients had, in comparison with CM patients, higher IL-10 and IL-12 levels. In contrast, IL-15 was generally below detection in most samples. These results provide further insight into the pathogenesis of complicated malaria by strengthening the contention that cytokines such as IL-10 and IL-12 are involved in modulating the immune response to P. falciparum.en_US
dc.description.affiliationDepartment of Immunology and Medicine, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.en_US
dc.identifier.citationGosi P, Khusmith S, Looareesuwan S, Sitachamroom U, Glanarongran R, Buchachart K, Walsh DS. Complicated malaria is associated with differential elevations in serum levels of interleukins 10, 12, and 15. The Southeast Asian Journal of Tropical Medicine and Public Health. 1999 Sep; 30(3): 412-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34701
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/1999-30-3/1999-30-3-412.pdfen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-10 --blooden_US
dc.subject.meshInterleukin-12 --blooden_US
dc.subject.meshInterleukin-15 --blooden_US
dc.subject.meshMalaria, Falciparum --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleComplicated malaria is associated with differential elevations in serum levels of interleukins 10, 12, and 15.en_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
tsajtmph_1999v30n3p412.pdf
Size:
89.19 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Southeast Asian Journal of Tropical Medicine and Public Health