Antiulcerogenic effect of Capparis cartillaginea decne on indomethacin induced gastric ulcer in wistar rats

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dc.contributor.authorMugo, Nancy W.en_US
dc.contributor.authorWangia, Christineen_US
dc.contributor.authorKikuvi, Gideonen_US
dc.contributor.authorNgugi, Samuelen_US
dc.date.accessioned2020-11-18T10:02:34Z
dc.date.available2020-11-18T10:02:34Z
dc.date.issued2020-10
dc.description.abstractBackground: Peptic ulcer disease is a non-malignant, mucosal lesion of the stomach or duodenum. The mucosal defect reaches the muscularis mucosa and sometimes, beyond causing life threatening complications, including haemorrhage, perforations, gastrointestinal obstruction and malignancy.Methods: The animals were pre-treated with omeprazole 20 mg/kg and 300 mg/kg of Capparis cartillaginea decne orally for 14 days. On the 15th day, ulcers were induced using indomethacin 30 mg/kg and 4 hours post ulcer induction, they were sacrificed. Ulcer index, pH, total acidity and volume were determined.Results: Extensive lesions were seen in indomethacin ulcerated rats with mean ulcer score of (1.260±0.18). In comparison, there were minimal areas of erosion on animals pre-treated with omeprazole (0.14±0.025) and plant extracts (0.280±0.097). Indomethacin-induced ulcer treated animals showed the highest volume of gastric juice output (3.14±0.21 ml), whereas the animals pre-treated with omeprazole had lower gastric juice output (2.20±0.2 9ml). This was comparable to animals pre-treated with the plant extract (1.80±0.13 ml). The pH was high in animals pre-treated with omeprazole (5.02±0.53). This was also seen in animals pre-treated with the extract (4.82±0.31). This was in comparison to the low pH seen in indomethacin ulcerated animals (2.20±0.16). Indomethacin-induced ulcer treated animals showed high levels of total acidity (88.64±1.71 mEq/L). Whereas the animals pre-treated with omeprazole had lower total acidity (55.26±3.77 mEq/L), which was also mirrored in animals pre-treated with the plant extracts (61.44±2.42 mEq/L).Conclusions: The extracts of Capparis cartillaginea decne showed anti-ulcer effect on indomethacin induced ulcers in Wistar rats.en_US
dc.identifier.affiliationsDepartment of Medical Physiology, Jomokenyatta University of Agriculture and Technology, Nairobi, Kenyaen_US
dc.identifier.affiliationsDepartment of Pharmacology and Pharmacognosy, Jomokenyatta University of Agriculture and Technology, Nairobi, Kenyaen_US
dc.identifier.affiliationsDepartment of Environmental Health and Disease Control, Jomokenyatta University of Agriculture and Technology, Nairobi, Kenyaen_US
dc.identifier.citationMugo Nancy W., Wangia Christine, Kikuvi Gideon, Ngugi Samuel. Antiulcerogenic effect of Capparis cartillaginea decne on indomethacin induced gastric ulcer in wistar rats. International Journal of Research in Medical Sciences. 2020 Oct; 8(10): 3445-3448en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/212619
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20204213en_US
dc.subjectIndomethacinen_US
dc.subjectOmeprazoleen_US
dc.subjectCaparris cartillaginea decneen_US
dc.subjectPeptic ulcersen_US
dc.titleAntiulcerogenic effect of Capparis cartillaginea decne on indomethacin induced gastric ulcer in wistar ratsen_US
dc.typeJournal Articleen_US
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