Self-reported treatment adherence in inflammatory bowel disease in Indian patients.
Loading...
Date
2009-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Introduction Non-adherence to medical therapy is emerging as an important determinant of relapse in patients with inflammatory bowel disease (IBD).
Aim To find the prevalence of and reasons for nonadherence
to medical therapy in Indian patients with IBD
and its correlation with disease outcome.
Methods In this cross-sectional study, we checked for
adherence to treatment in 127 patients with IBD (117 ulcerative
colitis and 10 Crohn’s disease) using a questionnaire
that inquired into frequency of missed doses, causes for missed
doses, and its relation to relapse of disease.
Results Of the 127 patients (mean age 42.8 years; 68
women), 103 (81%) were non-adherent to treatment, defined
as taking 80% or less of the dose advised. The reasons for
non-adherence (not mutually exclusive) were: forgetfulness–
98 patients (77%), felt better–18 (14.2 %), high frequency
of doses–13 (10.1%), no effect of medications–10 (7.87%),
non-availability of medications–3 (2.3%). Non-adherent
patients were three times more likely to develop a relapse
as compared to those with adherence (OR 3.389, 95% CI
1.29–8.88, p=0.012).
Conclusions Over 80% of patients with IBD in this survey
were non-adherent to medical treatment; forgetfulness was
mentioned as the most common cause. Non-adherent
patients were more likely to relapse. Patients need to be educated regarding the need for adherence to treatment in IBD.
Description
Keywords
Crohn’s disease, glucocorticoids, immunosuppressive agents, mesalamine, ulcerative colitis
Citation
Bhatt Jay, Patil Samir, Joshi Anand, Abraham Philip, Desai Devendra. Self-reported treatment adherence in inflammatory bowel disease in Indian patients. Indian Journal of Gastroenterology. 2009 Jul-Aug; 28(4): 143-146.