Testicular changes due to graded doses of nicotine in albino mice.

Simple item page
dc.contributor.authorReddy, Sen_US
dc.contributor.authorLondonkar, Ren_US
dc.contributor.authorRavindra,en_US
dc.contributor.authorReddy, Sen_US
dc.contributor.authorPatil, S Ben_US
dc.date.accessioned1998-04-04en_US
dc.date.accessioned2009-06-01T06:12:43Z
dc.date.available1998-04-04en_US
dc.date.available2009-06-01T06:12:43Z
dc.date.issued1998-04-04en_US
dc.description.abstractAdministration of graded doses of nicotine (0.2 mg, 0.4 mg and 0.6 mg/100 g body weight) for 15 days to the adult mice reduced the weight of testis, number of spermatocytes and spermatids, but increased the number of spermatogonia which may be due to reduced conversion to subsequent stages. There is a high cholesterol content and Sudanophilic lipid accumulation in the treated testis. The weight of accessory sex organs which is dependent on androgens produced by the testis is also reduced. These changes are brought because of the non-availability of pituitary gonadotrophins essential for initiation and completion of spermatogenesis and steroidogenesis in the testis due to the administration of nicotine, which being CNS depressor might have caused inhibition in the neural stimulus essential for release of pituitary gonadotrophins.en_US
dc.description.affiliationDepartment of Studies in Zoology, Gulbarga University.en_US
dc.identifier.citationReddy S, Londonkar R, Ravindra , Reddy S, Patil SB. Testicular changes due to graded doses of nicotine in albino mice. Indian Journal of Physiology and Pharmacology. 1998 Apr; 42(2): 276-80en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107211
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCholesterol --metabolismen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFollicle Stimulating Hormone --antagonists & inhibitorsen_US
dc.subject.meshLuteinizing Hormone --physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshNicotine --pharmacologyen_US
dc.subject.meshNicotinic Agonists --pharmacologyen_US
dc.subject.meshOrgan Size --drug effectsen_US
dc.subject.meshProstate --drug effectsen_US
dc.subject.meshSeminal Vesicles --drug effectsen_US
dc.subject.meshSpermatogenesis --drug effectsen_US
dc.subject.meshSpermatogonia --drug effectsen_US
dc.subject.meshTestis --drug effectsen_US
dc.titleTesticular changes due to graded doses of nicotine in albino mice.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Physiology and Pharmacology