A profile of bacteriologically confirmed pulmonary tuberculosis in children.

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dc.contributor.authorSwaminathan, Soumyaen_US
dc.contributor.authorDatta, Manjulaen_US
dc.contributor.authorRadhamani, M Pen_US
dc.contributor.authorMathew, Saraen_US
dc.contributor.authorReetha, A Men_US
dc.contributor.authorRajajee, Saralaen_US
dc.contributor.authorMathew, Remaen_US
dc.contributor.authorRadhakrishnan, Aen_US
dc.contributor.authorRaghu, M Ben_US
dc.date.accessioned2008-09-30en_US
dc.date.accessioned2009-05-27T05:55:37Z
dc.date.available2008-09-30en_US
dc.date.available2009-05-27T05:55:37Z
dc.date.issued2008-09-30en_US
dc.description.abstractOBJECTIVE: To describe the clinical profile of children with bacteriologically confirmed tuberculosis. STUDY DESIGN: A multicentric study was conducted in three hospitals in Chennai city between July 1995 and December 1997. Children aged 6 months to 12 years with signs and symptoms suggestive of tuberculosis were investigated further. Clinical examination, chest radiograph, tuberculin skin test with 1 TU PPD and, sputum or gastric lavage for mycobacterial smear and culture were done for all and, lymph node biopsy when necessary. RESULTS: A total of 2652 children were registered and tuberculosis was bacteriologically confirmed in 201. Predominant symptoms were history of an insidious illness (49%), fever and cough (47%), loss of weight (41%) and a visible glandular swelling (49%). Respiratory signs were few and 62% were undernourished. Over half the patients with confirmed TB had normal chest X-ray. Abnormal X-ray findings included parenchymal opacities in 47% and hilar or mediastinal lymphadenopathy in 26%. The prevalence of isoniazid resistance was 12.6% and MDR TB 4%. CONCLUSIONS: Children with tuberculosis present with fever and cough of insidious onset. Lymphadenopathy is a common feature even in children with pulmonary TB. A significant proportion of children have normal chest X-rays despite positive gastric aspirate cultures. Drug resistance rates in children mirror the pattern seen in adults in this geographic area.en_US
dc.description.affiliationDivision of HIV/AIDS, Tuberculosis Research Centre, Chetput, Chennai, India. doctorsoumya@yahoo.comen_US
dc.identifier.citationSwaminathan S, Datta M, Radhamani MP, Mathew S, Reetha AM, Rajajee S, Mathew R, Radhakrishnan A, Raghu MB. A profile of bacteriologically confirmed pulmonary tuberculosis in children. Indian Pediatrics. 2008 Sep; 45(9): 743-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/13958
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshBacteriological Techniquesen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshTuberculosis, Multidrug-Resistant --diagnosisen_US
dc.subject.meshTuberculosis, Pulmonary --diagnosisen_US
dc.titleA profile of bacteriologically confirmed pulmonary tuberculosis in children.en_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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