Role of environmental factors & oxidative stress with respect to in vitro fertilization outcome

Simple item page
dc.contributor.authorKumar, Sen_US
dc.contributor.authorMishra, Ven_US
dc.contributor.authorThaker, Ren_US
dc.contributor.authorGor, Men_US
dc.contributor.authorPerumal, Sen_US
dc.contributor.authorJoshi, Pen_US
dc.contributor.authorSheth, Hen_US
dc.contributor.authorShaikh, Ien_US
dc.contributor.authorGautam, AKen_US
dc.contributor.authorVerma, Yen_US
dc.date.accessioned2020-04-10T01:40:55Z
dc.date.available2020-04-10T01:40:55Z
dc.date.issued2018-12
dc.description.abstractBackground & objectives: Oxidative stress, lifestyle factors as also exposure to certain environmental factors are known to affect the fertility status in human beings. The aim of this study was to evaluate the role of OS and lifestyle and environmental factors affecting IVF outcome. Methods: A total of 253 couples were included, and biological samples such as blood, follicular fluid (FF), cumulus cells and semen were collected. Relevant biochemical parameters and metals namely lead (Pb), cadmium (Cd), copper (Cu) and zinc (Zn) were determined in the biological samples. ?-human chorionic gonadotropin levels ?100 IU/l were considered to predict viable pregnancy on the 15th day of embryo transfer (ET). Results: The mean body mass index (BMI) was significantly lower in females with positive IVF outcome compared to those with negative outcome. Couples residing in the residential area showed more percentage of positive IVF outcomes as compared to couples residing in industrial/agricultural area. FF Zn level was significantly higher (P<0.001) among the females' participants who have undergone ET as compared to those who have not undergone ET. FF MDA and serum Cu levels were significantly higher (P<0.05) in the female participants with negative IVF outcome as compared to positive IVF outcome. Logistic regression revealed that maternal BMI (P=0.034) and FF MDA level (P=0.047) were significantly associated with the IVF outcome. Interpretation & conclusions: The success rate of IVF was about 31.8 per cent, and BMI was significantly lower in females with positive outcome. The higher levels of MDA in FF and SP might have a negative impact on IVF outcome, higher Zn level in SP, FF and serum might have a positive role in embryo transfer as well as IVF outcome. The role of stress management and nutrition supplementation during the IVF treatment may be explored.en_US
dc.identifier.affiliationsDivision of Reproductive and Cytotoxicology, ICMR-National Institute of Occupational Health, Ahmedabad, Indiaen_US
dc.identifier.affiliationsDepartment of Gynaecology & Obstetrics, IVF Centre, Institute of Kidney Diseases and Research Centre, Ahmedabad, Indiaen_US
dc.identifier.affiliationsDivision of Pesticide, ICMR-National Institute of Occupational Health, Ahmedabad, Indiaen_US
dc.identifier.affiliationsDivision of Occupational Hygiene, ICMR-National Institute of Occupational Health, Ahmedabad, Indiaen_US
dc.identifier.citationKumar S, Mishra V, Thaker R, Gor M, Perumal S, Joshi P, Sheth H, Shaikh I, Gautam AK, Verma Y. Role of environmental factors & oxidative stress with respect to in vitro fertilization outcome. Indian Journal of Medical Research. 2018 Dec; 148(7): 125-133en_US
dc.identifier.issn0971-5916
dc.identifier.issn0975-9174
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/195744
dc.languageenen_US
dc.publisherIndian Council of Medical Researchen_US
dc.relation.issuenumber7en_US
dc.relation.volume148en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.IJMR_1864_17en_US
dc.subject?-human chorionic gonadotropinen_US
dc.subjectDNA damageen_US
dc.subjectembryo transferen_US
dc.subjectheavy metals and trace metalsen_US
dc.subjectin vitro fertilization outcomeen_US
dc.subjectoocyte retrievalen_US
dc.subjectoxidative stressen_US
dc.titleRole of environmental factors & oxidative stress with respect to in vitro fertilization outcomeen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijmr2018v148n7p125.pdf
Size:
728.88 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Medical Research