Assessment of Acute Phase Protein Serum hs-CRP Levels and its Role in Severity of Disease in Vitiligo Patients – A Hospital Based Case Control Study in M.Y. Hospital, Indore M.P.

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dc.contributor.authorSarkar, P. Deyen_US
dc.contributor.authorTiwari, Bhavanaen_US
dc.contributor.authorLohokare, Rajeeven_US
dc.contributor.authorKhare, Sanjayen_US
dc.contributor.authorPaneri, Sangeetaen_US
dc.contributor.authorVarma, Vandanaen_US
dc.date.accessioned2020-09-24T07:12:04Z
dc.date.available2020-09-24T07:12:04Z
dc.date.issued2020-02
dc.description.abstractIntroduction: Vitiligo an acquired pigmentary disorderof the skin and mucous membranes characterized by wellcircumscribed, depigmented macules and patches resultingfrom selective destruction of melanocytes. CRP is an acutephase protein secreted by the liver in response to severalinflammatory cytokines such as IL6. Since inflammatoryand immune factors plays a key role in the pathogenesis ofvitiligo, we aimed to assess the relationship between theserum level of hs-CRP and pathogenesis and severity ofvitiligo.Material and methods: The study was conducted in theDept. of Biochemistry and Dept. of Dermatology andVenereology in MGM Medical College & M Y HospitalIndore after approval from ethical committee on 70Confirmed & diagnosed cases of Vitiligo patients of agegroup 18 to 55 years attending Dermatology OPD in MYHospital Indore during a period of April 2018 to April 2019.Patients were divided into three groups according to thearea of skin affected. Healthy individual without vitiligowere taken as controls. Venous blood sample was analyzedfor serum hs-CRP levels and liver function. Appropriatestatistical tests were applied on Minitab Version 17.0 and pvalues < 0.01was considered significant.Results: In our study the mean serum hs-CRP in case groupwas higher 12.09 ± 11.64 than in control group it was 1.99 ±2.05 with negative but statistically significant correlation withage of onset of disease and positive statistically significantcorrelation with duration of disease thus, serum hs-CRPlevel might be useful for evaluating the disease activity ofvitiligo as Novel biomarker.Conclusion: As high-sensitive C-reactive protein (hs-CRP)is an important sensitive diagnostic and prognostic markerin many systemic inflammatory diseases and very lowconcentrations of hs-CRP can be analyzed in the serum, itsdetection and serial measurements helps to provide a novellink to evaluate the disease activity and severity and responseto treatmenten_US
dc.identifier.affiliationsProfessor & HOD, Department of Biochemistry M.G.M. Medical College and M.Y. Hospital, Indore, M.Pen_US
dc.identifier.affiliationsPG Resident, Department of Biochemistry, M.G.M. Medical College and M.Y. Hospital, Indore, M.Pen_US
dc.identifier.affiliationsAssociate Professor, Department of Biochemistry, M.G.M. Medical College and M.Y. Hospital, Indore, M.Pen_US
dc.identifier.affiliationsProfessor, Department of Dermatology and venereology, M.G.M. Medical College and M.Y. Hospital, Indore, M.Pen_US
dc.identifier.affiliationsProfessor, Department of Biochemistry M.G.M. Medical College and M.Y. Hospital, Indore, M.Pen_US
dc.identifier.affiliationsAssociate Professor, Department of Biochemistry M.G.M. Medical College and M.Y. Hospital, Indore, M.P., Indiaen_US
dc.identifier.citationSarkar P. Dey, Tiwari Bhavana, Lohokare Rajeev, Khare Sanjay, Paneri Sangeeta, Varma Vandana. Assessment of Acute Phase Protein Serum hs-CRP Levels and its Role in Severity of Disease in Vitiligo Patients – A Hospital Based Case Control Study in M.Y. Hospital, Indore M.P.. International Journal of Contemporary Medical Research . 2020 Feb; 7(2): b1-b5en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/202838
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber2en_US
dc.relation.volume7en_US
dc.source.uri​https://dx.doi.org/10.21276/ijcmr.2020.7.2.21en_US
dc.subjectVitiligoen_US
dc.subjecths-CRPen_US
dc.subjectMelanocyte Cytokinesen_US
dc.subjectInflammationen_US
dc.titleAssessment of Acute Phase Protein Serum hs-CRP Levels and its Role in Severity of Disease in Vitiligo Patients – A Hospital Based Case Control Study in M.Y. Hospital, Indore M.P.en_US
dc.typeJournal Articleen_US
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