Clinical and metabolic characteristics of males with early-onset androgenetic alopecia

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dc.contributor.authorKeshavamurthy, Vinayen_US
dc.contributor.authorBhattachajee, Rajsmitaen_US
dc.contributor.authorBishnoi, Anuradhaen_US
dc.contributor.authorKaushik, Akankshaen_US
dc.contributor.authorSachdeva, Nareshen_US
dc.contributor.authorPal, Arnaben_US
dc.contributor.authorNarang, Tarunen_US
dc.contributor.authorDogra, Sunilen_US
dc.date.accessioned2023-08-10T07:30:55Z
dc.date.available2023-08-10T07:30:55Z
dc.date.issued2023-08
dc.description.abstractBackground: Men with early-onset androgenetic alopecia (AGA) often have an abnormal hormonal milieu. Objective: To ascertain the clinico-phenotypic characteristics and the prevalence of hormonal and metabolic changes in men with early-onset AGA. Methods: Consecutive male patients less than 30 years of age with a Norwood-Hamilton grade ?3 AGA were recruited in this comparative cross-sectional study. After endocrine evaluation they were classified into two groups, that is, Group A consisting of subjects with an altered hormonal profile and Group B with normal hormonal profiles. The groups were assessed for differences in disease phenotype and severity (Norwood-Hamilton grade), insulin resistance and parameters of metabolic syndrome (ATP III guidelines). Results: Altered hormonal profiles were seen in 34 of the 100 subjects with AGA, while insulin resistance and metabolic syndrome were noted in 44 and 26 respectively. Altered hormonal profiles were significantly associated with insulin resistance and severe alopecia (grade 4 and above Hamilton-Norwood Scale). Insulin resistant Group A patients had a significantly higher prevalence of severe alopecia (>grade 4) (P = 0.0036). The prevalence of metabolic syndrome was similar in both groups. Limitation: The cross sectional study design was a drawback of this study. Further, a control arm without AGA was not included and the sample size of 100 was selected arbitrarily. Conclusion: An altered hormonal profile and insulin resistance was noted in a third of the males with early-onset AGA. Subjects with altered hormonal profiles had a higher prevalence of insulin resistance and were likely to have severe grades of AGAen_US
dc.identifier.affiliationsDepartments of Dermatology, Venereology and Leprologyen_US
dc.identifier.affiliationsEndocrinology, anden_US
dc.identifier.affiliationsBiochemistry, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, Indiaen_US
dc.identifier.citationKeshavamurthy, Vinayen_US
dc.identifier.citationBhattachajee, Rajsmitaen_US
dc.identifier.citationBishnoi, Anuradhaen_US
dc.identifier.citationKaushik, Akankshaen_US
dc.identifier.citationSachdeva, Nareshen_US
dc.identifier.citationPal, Arnaben_US
dc.identifier.citationNarang, Tarunen_US
dc.identifier.citationDogra, Sunil. Clinical and metabolic characteristics of males with early-onset androgenetic alopecia. Indian Journal of Dermatology, Venereology and Leprology. 2023 Aug; 89(4): 530-535en_US
dc.identifier.issn0973-3922
dc.identifier.issn0378-6323
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223154
dc.languageenen_US
dc.publisherScientific Scholaren_US
dc.relation.issuenumber4en_US
dc.relation.volume89en_US
dc.source.urihttps://doi.org/10.25259/IJDVL_949_2021en_US
dc.subjectAndrogenetic alopeciaen_US
dc.subjectearly onseten_US
dc.subjecthormonal disturbanceen_US
dc.subjectinsulin resistanceen_US
dc.subjectmale androgenetic alopeciaen_US
dc.subjectmetabolic syndromeen_US
dc.titleClinical and metabolic characteristics of males with early-onset androgenetic alopeciaen_US
dc.typeJournal Articleen_US
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