Effect of prophylactic amiodarone in patients with rheumatic valve disease undergoing valve replacement surgery.

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dc.contributor.authorKar, Sandeep Kumar
dc.contributor.authorDasgupta, Chaitali Sen
dc.contributor.authorGoswami, Anupam
dc.date.accessioned2012-07-18T04:45:45Z
dc.date.available2012-07-18T04:45:45Z
dc.date.issued2011-09
dc.description.abstractThe study was carried out to evaluate the effect of prophylactic single-dose intravenous amiodarone in patients undergoing valve replacement surgery. Maintenance of sinus rhythm is better than maintenance of fixed ventricular rate in atrial fibrillation (AF) especially in the presence of irritable left or right atrium because of enlargement. Fifty-six patients with valvular heart disease with or without AF were randomly divided into two groups. Group I or the amiodarone group (n=28) received amiodarone (3 mg/kg in 100 ml normal saline) and group II or the control group received same volume of normal saline. The standardized protocol for cardiopulmonary bypass was maintained for all the patients. AF occurred in 7.14% patients in group I, and in group II, 28.57% (P=0.035); ventricular tachycardia/fibrillation was observed in 21.43% patients in group I and 46.43% patients in group II (P=0.089) after release of aortic clamp. Most of the patients in group I (92.86%) maintained sinus rhythm without cardioversion or defibrillation after release of aortic cross clamp (P=0.002). Defibrillation or cardio version was needed in 7.14% patients in group I and 28.57% patients in group II (P=0.078). A single prophylactic intraoperative dose of intravenous amiodarone decreased post bypass arrhythmia in this study in comparison to the control group. Single dose of intraoperative amiodarone may be used to decrease postoperative arrhythmia in open heart surgery.en_US
dc.identifier.citationKar Sandeep Kumar, Dasgupta Chaitali Sen, Goswami Anupam. Effect of prophylactic amiodarone in patients with rheumatic valve disease undergoing valve replacement surgery. Annals of Cardiac Anaesthesia. 2011 Sept; 14(3): 176-182.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/139605
dc.language.isoenen_US
dc.source.urihttps://www.annals.in/article.asp?issn=0971-9784;year=2011;volume=14;issue=3;spage=176;epage=182;aulast=Karen_US
dc.subjectAmiodaroneen_US
dc.subjectatrial fibrillationen_US
dc.subjectcardiac arrhythmiasen_US
dc.subjectcardiacen_US
dc.subjectcardiopulmonary bypassen_US
dc.subjectdimensionen_US
dc.subjectleft atriumen_US
dc.subjectprophylacticen_US
dc.subjectsurgeryen_US
dc.subjectventricular rateen_US
dc.subject.meshAdult
dc.subject.meshAmiodarone --therapeutic use
dc.subject.meshAnti-Arrhythmia Agents --therapeutic use
dc.subject.meshAtrial Fibrillation --physiopathology
dc.subject.meshAtrial Fibrillation --prevention & control
dc.subject.meshCardiopulmonary Bypass
dc.subject.meshElectric Countershock
dc.subject.meshFemale
dc.subject.meshHeart Valve Prosthesis Implantation --methods
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRheumatic Heart Disease --surgery
dc.titleEffect of prophylactic amiodarone in patients with rheumatic valve disease undergoing valve replacement surgery.en_US
dc.typeArticleen_US
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