Predictor of outcome of hyperthyroidism due to Graves disease: serum triiodothyronine/thyroxine ratio.

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dc.contributor.authorKhanna, C Men_US
dc.contributor.authorShankar, L Ren_US
dc.contributor.authorJaggi, C Ben_US
dc.contributor.authorBansal, J Ken_US
dc.contributor.authorChugh, Pen_US
dc.date.accessioned1996-02-01en_US
dc.date.accessioned2009-05-31T05:04:47Z
dc.date.available1996-02-01en_US
dc.date.available2009-05-31T05:04:47Z
dc.date.issued1996-02-01en_US
dc.description.abstractThere is a proportionally greater increase in the serum T3 than Serum T4 concentration in patients with hyperthyroidism due to Grave's disease which results in an elevation of serum T3 to T4 ratio. The study was undertaken to investigate the alteration of serum T3 to T4 ratio in relation to the outcome of antithyroid drug therapy. 98 patients of hyperthyroid Grave's disease were studied and 78 patients had T3 to T4 ratio greater than 20 ng/microgram before therapy (normal range 14-20; mean 16.0) In 16 out of 78 patient T3 to T4 ratio remained high during a 18 months course of antithyroid drug therapy and in 13 of them (81%) hyperthyroidism recurred after stoppage of treatment. In the remaining 62 patients, the initial high T3 to T4 ratio became normal (< 20) during treatment and 34 of them (54.9%) had a remission of the disease after stoppage of the drug. Of the 20 patients in whom the initial T3 to T4 ratios were within normal range, the ratio remained normal during treatment and 16(80%) had a remission. Goiter size was larger in patients with high serum T3 to T4 ratio and reduction of goiter size occurred in some patients (59%) with decreasing T3 to T4 ratios. It is concluded that serum T3 to T4 ratio is a single and a useful predictor of the outcome of antithyroid drug therapy in patients with hyperthyroidism due to Grave's disease. A ratio greater than 20 throughout therapy indicates that the chances of relapse is high and a ratio below 20 either initially or during therapy is an indication of prolonged remission.en_US
dc.description.affiliationDept. of Endrocrinology, Institute of Nuclear Medicine and Allied Science, Delhi.en_US
dc.identifier.citationKhanna CM, Shankar LR, Jaggi CB, Bansal JK, Chugh P. Predictor of outcome of hyperthyroidism due to Graves disease: serum triiodothyronine/thyroxine ratio. Journal of the Association of Physicians of India. 1996 Feb; 44(2): 98-101en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/95283
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntithyroid Agents --administration & dosageen_US
dc.subject.meshBiological Markers --analysisen_US
dc.subject.meshEvaluation Studies as Topicen_US
dc.subject.meshFemaleen_US
dc.subject.meshGraves Disease --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrognosisen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshThyroxine --analysisen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshTriiodothyronine --analysisen_US
dc.titlePredictor of outcome of hyperthyroidism due to Graves disease: serum triiodothyronine/thyroxine ratio.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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