Human genetic variation and personalized medicine.

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dc.contributor.authorAgrawal, Surakshaen_US
dc.contributor.authorKhan, Faisalen_US
dc.date.accessioned2007-01-20en_US
dc.date.accessioned2009-06-01T07:58:08Z
dc.date.available2007-01-20en_US
dc.date.available2009-06-01T07:58:08Z
dc.date.issued2007-01-20en_US
dc.description129 references.en_US
dc.description.abstractHuman genome sequencing results revealed an insight into the role of human genetic variation behind differential susceptibility of human diseases, differential response to pharmacological agents and presence of varied phenotypes. This leads to the concept of personalized medicine. In the present review we have discussed the objectives and approaches for carrying out pharmacogenomics and pharmacogenetics studies. The review also incorporates the major findings categorizing the common diseases on the basis of genetic profiles and ethnic information and in establishing personalized disease diagnosis, drug responses and treatment modalities based on the genetic determinants. Overall an attempt has been made to highlight the importance of studying the genetic profiles of an individual in biomedical and pharmacogenomics research.en_US
dc.description.affiliationDepartment of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow. suraksha@sgpgi.ac.inen_US
dc.identifier.citationAgrawal S, Khan F. Human genetic variation and personalized medicine. Indian Journal of Physiology and Pharmacology. 2007 Jan-Mar; 51(1): 7-28en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108559
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshDrug Therapy --methodsen_US
dc.subject.meshGenetic Predisposition to Disease --ethnologyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshPharmaceutical Preparations --administration & dosageen_US
dc.subject.meshPharmacogenetics --methodsen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleHuman genetic variation and personalized medicine.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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