Efficacy of Pyridoxine in Early-Onset Idiopathic Intractable Seizures in Children.

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dc.contributor.authorMishra, Devendra
dc.contributor.authorKalra, Veena
dc.contributor.authorSeth, Rachna
dc.contributor.authorGulati, Sheffali
dc.contributor.authorSaha, Narayan
dc.date.accessioned2015-03-24T11:11:47Z
dc.date.available2015-03-24T11:11:47Z
dc.date.issued2010-11
dc.description.abstractObjective To identify pyridoxine responsive seizures among children with early onset intractable seizures, and to identify pyridoxine-dependency as a subset in this group. Methods Patients with neonatal onset idiopathic, intractable seizures were identified over a 6-month period and subjected to a ‘pyridoxine trial’, at the Pediatric Neurology Clinic of a tertiary-care teaching hospital in New Delhi, India. This consisted of an intravenous infusion of 100 mg of pyridoxine over 10-min with a simultaneous EEG monitoring. This procedure was carried out in the EEG laboratory with all appropriate precautions (including availability of resuscitation Results 621 children with active epilepsy were seen at the PNC, of which 48 had early-onset, medical intractable epilepsy, and 21 children (13 males and 8 females), aged between 11 month and 38 month were enrolled. The median age at onset of seizure was 5.1 months. The major seizure type was focal in 3 and generalized in 18 (including infantile spasm in 11). No patient had normalization of EEG during the ‘trial’. Two patients (9.5%) had a response during the 2 weeks of oral treatment and oral therapy was continued. No toxicity or side-effects of pyridoxine were observed in these two patients over a follow-up of more than 18 months. Conclusions Pyridoxine responsive seizures contribute a significant proportion to early-onset idiopathic intractable epilepsy in childhood. Routine use of pyridoxine in the management of early onset resistant seizures would go a long way in identifying these patients early.en_US
dc.identifier.citationMishra Devendra, Kalra Veena, Seth Rachna, Gulati Sheffali, Saha Narayan. Efficacy of Pyridoxine in Early-Onset Idiopathic Intractable Seizures in Children. Indian Journal of Pediatrics. 2010 Nov ; 77 (11): 1252-1256.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/157171
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/icb/t10/i11/icbt10i11p1252.pdfen_US
dc.subjectAntiepileptic drugsen_US
dc.subjectIndiaen_US
dc.subjectInfantile spasmsen_US
dc.subjectPyridoxineen_US
dc.subjectResistant epilepsyen_US
dc.titleEfficacy of Pyridoxine in Early-Onset Idiopathic Intractable Seizures in Children.en_US
dc.typeArticleen_US
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