Effect of Pre-treatment with Moringa oleifera (Drumstick) Leaves on Diabetogenesis Produced by Alloxan in Rats.
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Date
2015-07
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Abstract
Background: Medicinal plants constitute an important source of potential therapeutic
agents for diabetes. Objective: In the study, we aimed to investigate the pre-treatment
effect or preventive effects of Moringa oleifera (MO) leaves on blood sugar of rats.
Materials and method: This experimental study was carried out in the department of
Pharmacology and Therapeutics of Sir Salimullah Medical College in collaboration
with Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka. A total
24 long Evans rats were included in this study and divided in to four groups.
Hyperglycemia was induced on rats using alloxan (100 mg/kg body weight,
intraperitioneally). Blood sample was collected from tail vein by tail tipping method.
Pre-treatment effect or preventive role of Moringa oleifera (drumstick) leaf powder on
diabetogenesis produced by Alloxan in rats was tested by giving 50 mg/rat/day Moringa
oleifera leaf powder for 14 days orally as pre-treatment along with standard rat feed.
Then alloxan was administered intraperitoneally on 15th day of the experiment and
50mg/rat/day Moringa oleifera leaf powder was given for 7 days as post-treatment.
Results: No significant effect of MO on blood glucose level was observed on normal rats
and non significant hypoglycaemic effect was found in rats that were pretreated with
MO. Conclusion: The present study suggests that Moringa oleifera leaf powder did not
produce any significant protective effect in diabetogenesis produced by alloxan though
it has hypoglycaemic effect.
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Keywords
Plants, oleifera leaf, diabetogenesis
Citation
Nahar Shamsun, Parveen Feroza, Ara Ferdous, Faisal Ferdous Mahmud. Effect of Pre-treatment with Moringa oleifera (Drumstick) Leaves on Diabetogenesis Produced by Alloxan in Rats. Delta Medical College Journal. 2015 July; 3(2): 63-67.