Chromosome investigations & clinical outcome in patients with myelodysplastic syndromes.

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dc.contributor.authorKadam, Pen_US
dc.contributor.authorDadabhoy, Ken_US
dc.contributor.authorBhisey, Aen_US
dc.contributor.authorAthale, Uen_US
dc.contributor.authorNair, Cen_US
dc.contributor.authorNair, Ren_US
dc.contributor.authorAdvani, Sen_US
dc.date.accessioned1995-04-01en_US
dc.date.accessioned2009-05-27T08:14:24Z
dc.date.available1995-04-01en_US
dc.date.available2009-05-27T08:14:24Z
dc.date.issued1995-04-01en_US
dc.description.abstractA total of 25 patients with primary myelodysplastic syndrome (p-MDS) were cytogenetically investigated. The incidence of abnormal karyotypes was higher, detected in 88 per cent of the patients and the most frequent abnormality was a terminal deletion of chromosome 7 (45% of the patients with abnormal karyotypes) followed by an i (17q) (18%), +21(14%), -5/5q (9%), del (11) (q22) (9%). Cytogenetic analysis after therapy/after leukaemic transformation indicated either stable clones (2 patients) or emergence of new clones such as inv(5) (q32q36), del (17) (p13), +20, +22 (1 patient each). It is to be noted that of the 8 patients with leukaemic transformation, 5 had del (7q). The leukaemic transformation (32% of the patients) was not related to the percentage of abnormal karyotypes not to the percentage of blasts at the time of the MDS presentation. Chromosome instability was shown by 10 (45%) patients. Our data indicate that higher frequency of chromosomal aberrations with involvement of chromosome 7 may be the result of underlying disease.en_US
dc.description.affiliationDepartment of Medical Oncology, Tata Memorial Hospital, Bombay.en_US
dc.identifier.citationKadam P, Dadabhoy K, Bhisey A, Athale U, Nair C, Nair R, Advani S. Chromosome investigations & clinical outcome in patients with myelodysplastic syndromes. Indian Journal of Medical Research. 1995 Apr; 101(): 163-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/23741
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyelodysplastic Syndromes --geneticsen_US
dc.titleChromosome investigations & clinical outcome in patients with myelodysplastic syndromes.en_US
dc.typeJournal Articleen_US
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