Genetics of cholera toxin.

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dc.contributor.authorKaper, J Ben_US
dc.contributor.authorSrivastava, B Sen_US
dc.date.accessioned1992-07-01en_US
dc.date.accessioned2009-05-27T08:12:47Z
dc.date.available1992-07-01en_US
dc.date.available2009-05-27T08:12:47Z
dc.date.issued1992-07-01en_US
dc.description47 references.en_US
dc.description.abstractCholera is caused by the toxin secreted by Vibrio cholerae 01. Cholera toxin (CT) is a protein consisting of A and B subunits. The former contributes to intracellular toxicity whereas the B subunit is required for binding of CT to eukaryotic cell surface receptor. The structural genes encoding A and B subunits are designated as ctxA and ctxB respectively. These genes are located on the chromosome forming an operon in which ctxA precedes ctxB. The ctxAB have been cloned and sequenced. Classical strains contain two full copies of unlinked ctxAB. Most el tors have single copy. However, in some strains there are two copies which are arranged in tandem. The tandem duplication and amplification of ctxAB is controlled by a transposable element like DNA sequence called RS1. A number of genes have been identified which regulate the expression of ctx operon. V. cholerae seems to elaborate more than one toxin which are different from the one encoded by ctxAB genes.en_US
dc.description.affiliationCenter for Vaccine Development, University of Maryland, Baltimore.en_US
dc.identifier.citationKaper JB, Srivastava BS. Genetics of cholera toxin. Indian Journal of Medical Research. 1992 Jul; 95(): 163-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/23644
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCholera Toxin --geneticsen_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshGene Expression Regulation, Bacterialen_US
dc.subject.meshGenes, Bacterialen_US
dc.subject.meshGenes, Regulatoren_US
dc.subject.meshHumansen_US
dc.subject.meshRepetitive Sequences, Nucleic Aciden_US
dc.subject.meshVibrio cholerae --geneticsen_US
dc.titleGenetics of cholera toxin.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.typeReviewen_US
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