Optical coherence tomography features and correlation of functional and structural parameters in patients of idiopathic intracranial hypertension

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dc.contributor.authorBanerjee, Mousumien_US
dc.contributor.authorPhuljhele, Swatien_US
dc.contributor.authorSaluja, Gunjanen_US
dc.contributor.authorKumar, Pawanen_US
dc.contributor.authorSaxena, Rohiten_US
dc.contributor.authorSharma, Pradeepen_US
dc.contributor.authorVibha, Deeptien_US
dc.contributor.authorPandit, Awadh Kishoren_US
dc.date.accessioned2023-08-25T06:32:39Z
dc.date.available2023-08-25T06:32:39Z
dc.date.issued2022-04
dc.description.abstractPurpose: To determine the correlation between functional parameters and optical coherence tomography (OCT) features in patients of idiopathic intracranial hypertension (IIH). Methods: A prospective observational study in early and established cases of papilledema in IIH presenting from December 2017 to February 2019. Functional parameters (visual acuity, contrast sensitivity, mean deviation, VER, and MfERG) and structural parameters (RNFL, GCL?IPL, and optic disc height) were measured at baseline and every 6 weeks for 6 months. Results: At baseline, average RNFL had a moderate negative correlation with mean deviation (r = ?0.45; P = 0.0007) and a positive correlation with logMAR visual acuity (r = 0.18; P = 0.17). On the contrary, baseline GCL and logMAR visual acuity had a negative correlation (r = ?0.4, P = 0.02). Optic disc height (ODH) had a negative correlation with visual field mean deviation (r = ?0.046; P = 0.0005). At 6 months, ODH and GCL?IPL complex had a statistically significant correlation with functional parameters. However, RNFL values did not show any significant correlation with any of the functional parameters. Baseline GCL?IPL and optic disc height values had a moderate and significant correlation with final functional parameters. However, RNFL did not show any correlation with final functional parameters. Correlation between GCL?IPL thickness at 6 weeks and final functional parameters were stronger than that with baseline GCL values. Conclusion: In the setting of severe papilledema, RNFL can misguide the prognosis. GCL?IPL can be a valuable tool for an objective evaluation of the integrity of the optic nerve in IIH and ODH may be used as an alternative or in combination with GCL?IPL in these cases.en_US
dc.identifier.affiliationsDr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Neurology, AIIMS, New Delhi, Indiaen_US
dc.identifier.citationBanerjee Mousumi, Phuljhele Swati, Saluja Gunjan, Kumar Pawan, Saxena Rohit, Sharma Pradeep, Vibha Deepti, Pandit Awadh Kishor. Optical coherence tomography features and correlation of functional and structural parameters in patients of idiopathic intracranial hypertension. Indian Journal of Ophthalmology. 2022 Apr; 70(4): 1343-1349en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224257
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber4en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_2103_21en_US
dc.subjectGCL?IPLen_US
dc.subjectIIHen_US
dc.subjectOCTen_US
dc.subjectoptic disc heighten_US
dc.subjectRNFLen_US
dc.titleOptical coherence tomography features and correlation of functional and structural parameters in patients of idiopathic intracranial hypertensionen_US
dc.typeJournal Articleen_US
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