Prophylactic efficacy and possible mechanisms of oligosaccharides based standardized fenugreek seed extract on high-fat diet-induced insulin resistance in C57BL/6 mice.

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dc.contributor.authorKandhare, Amit D
dc.contributor.authorBodhankar, Subhash L
dc.contributor.authorMohan, Vishwaraman
dc.contributor.authorThakurdesai, Prasad A
dc.date.accessioned2015-07-06T09:10:49Z
dc.date.available2015-07-06T09:10:49Z
dc.date.issued2015-03
dc.description.abstractThe present work was aimed to study the efficacy and possible mechanism of oligosaccharides based standardized fenugreek seed extract (SFSE-OS) on high-fat diet (HFD)-induced insulin resistance in male C57BL/6 mice. The effects of 12 weeks of oral administration of SFSE-OS (30, 60 and 100 mg/kg, twice daily) were evaluated on HFD fed mice for anthropomorphic, glycemic, gene expression related and histopathological parameters. Separate groups of mice with vehicle co-administered with HFD and low-fat diet (LFD) were maintained as HFD control and LFD control respectively. Twelve weeks of SFSE-OS (60 and 100 mg/kg, p.o.) administration showed significant prophylactic effects on HFD induced insulin resistance in terms of body weight, plasma glucose and insulin levels, glycated hemoglobin, insulin resistance (IR), area under the curve (AUC) of plasma glucose during oral glucose tolerance and intraperitoneal insulin tolerance. Furthermore, HFDinduced mRNA expression changes in adipose tissue, liver and skeletal muscle were prevented by SFSE-OS coadministration. Histology of sections of the pancreas showed the normal architecture in all groups of mice. SFSE-OS showed promising efficacy in prevention of HFD-induced insulin resistance through modulation of Glut-2, Glut-4, IRS-2 and SREBP-1c expression.en_US
dc.identifier.citationKandhare Amit D, Bodhankar Subhash L, Mohan Vishwaraman, Thakurdesai Prasad A. Prophylactic efficacy and possible mechanisms of oligosaccharides based standardized fenugreek seed extract on high-fat diet-induced insulin resistance in C57BL/6 mice.Journal of Applied Pharmaceutical Science. 2015 Mar; 5(3): 35-45.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/159134
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=1451en_US
dc.subjectFenugreek seedsen_US
dc.subjectOligosaccharidesen_US
dc.subjectHigh-fat dieten_US
dc.subjectInsulin resistanceen_US
dc.subjectGlut-2en_US
dc.subjectGlut-4en_US
dc.subjectIRS-2en_US
dc.subjectSREBP-1cen_US
dc.titleProphylactic efficacy and possible mechanisms of oligosaccharides based standardized fenugreek seed extract on high-fat diet-induced insulin resistance in C57BL/6 mice.en_US
dc.typeArticleen_US
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