Pathways for protection from noise induced hearing loss.

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dc.contributor.authorLe Prell, C Gen_US
dc.contributor.authorDolan, D Fen_US
dc.contributor.authorSchacht, Jen_US
dc.contributor.authorMiller, J Men_US
dc.contributor.authorLomax, M Ien_US
dc.contributor.authorAltschuler, R Aen_US
dc.date.accessioned2003-07-16en_US
dc.date.accessioned2009-06-03T14:40:03Z
dc.date.available2003-07-16en_US
dc.date.available2009-06-03T14:40:03Z
dc.date.issued2003-07-16en_US
dc.description130 references.en_US
dc.description.abstractThere is increasing evidence that at least one function of both the medial and the lateral olivocochlear efferent systems is to provide adjustment of the set point of activity in their postsynaptic target, the outer hair cells and afferent processes, respectively. New results, summarized in this review, suggest that both efferent systems can provide protection from noise through this mechanism. There are also intracellular pathways that can provide protection from noise-induced cellular damage in the cochlea. This review also summarizes new results on the pathways that regulate and react to levels of reactive oxygen species in the cochlea as well as the role of stress pathways for the heat shock proteins and for neurotrophic factors in protection, recovery and repair.en_US
dc.description.affiliationKHRI, University of Michigan, 1301 East Ann, Ann Arbor, MI 48109-0506, USA.en_US
dc.identifier.citationLe Prell CG, Dolan DF, Schacht J, Miller JM, Lomax MI, Altschuler RA. Pathways for protection from noise induced hearing loss. Noise & Health. 2003 Jul-Sep; 5(20): 1-17en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/122066
dc.language.isoengen_US
dc.source.urihttps://www.noiseandhealth.orgen_US
dc.subject.meshAcoustic Stimulationen_US
dc.subject.meshAction Potentialsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCochlea --anatomy & histologyen_US
dc.subject.meshHearing Loss, Noise-Induced --prevention & controlen_US
dc.subject.meshHeat-Shock Proteins --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshOxidative Stress --physiologyen_US
dc.subject.meshReactive Oxygen Species --metabolismen_US
dc.titlePathways for protection from noise induced hearing loss.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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