Oxidative stress in sepsis in children.

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dc.contributor.authorCherian, Suminaen_US
dc.contributor.authorJameson, Shijien_US
dc.contributor.authorRajarajeswari, Chitikinenien_US
dc.contributor.authorHelena, Vemurien_US
dc.contributor.authorLatha, Lakshmien_US
dc.contributor.authorAnu Rekha, M Ren_US
dc.contributor.authorNagamma, Takkellaen_US
dc.contributor.authorSubba Raju, Ven_US
dc.contributor.authorKini, Pushpa Gen_US
dc.contributor.authorRao, Anjalien_US
dc.date.accessioned2007-02-14en_US
dc.date.accessioned2009-05-27T08:06:46Z
dc.date.available2007-02-14en_US
dc.date.available2009-05-27T08:06:46Z
dc.date.issued2007-02-14en_US
dc.description.abstractBACKGROUND & OBJECTIVE: Information on oxidative damage during sepsis in children is not available, we undertook this study to assess the levels of certain antioxidants in blood of children with sepsis. METHODS: Study group had 38 children with sepsis (<5 yr) and 39 age-and sex-matched controls admitted to a tertiary care hospital. Red cell glutathione (GSH), superoxide dismutase (SOD) and thiobarbituric acid reactive substance (TBARS) and plasma vitamin C were estimated by standard techniques. RESULTS: There was no significant change in erythrocyte GSH, SOD and TBARS levels in sepsis when compared to controls. This may be due to the adaptive response of the body to combat the oxidative stress. However, plasma vitamin C levels were significantly reduced in patients aged one year one month to five years which may be due to active phagocytosis and due to its role as a free radical scavenger. INTERPRETATION & CONCLUSION: Our findings show that children affected by sepsis probably adapt to the free radical toxicity induced by this condition. Further studies need to be done on a larger sample to confirm the findings.en_US
dc.description.affiliationDepartments of Biochemistry, Kasturba Medical College & Hospital, Manipal 576104, India.en_US
dc.identifier.citationCherian S, Jameson S, Rajarajeswari C, Helena V, Latha L, Anu Rekha MR, Nagamma T, Subba Raju V, Kini PG, Rao A. Oxidative stress in sepsis in children. Indian Journal of Medical Research. 2007 Feb; 125(2): 143-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/23279
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAscorbic Acid --blooden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshGlutathione --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshLipid Peroxidation --immunologyen_US
dc.subject.meshOxidative Stress --immunologyen_US
dc.subject.meshSepsis --immunologyen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshSuperoxide Dismutase --blooden_US
dc.subject.meshThiobarbituric Acid Reactive Substances --analysisen_US
dc.titleOxidative stress in sepsis in children.en_US
dc.typeJournal Articleen_US
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