Male systemic lupus erythematosus, rapidly progressive glomerulonephritis, and iatrogenic acute bone marrow failure: a case report

Simple item page
dc.contributor.authorDas, UKen_US
dc.contributor.authorChowdhury, EH.en_US
dc.date.accessioned2025-05-12T08:25:52Z
dc.date.available2025-05-12T08:25:52Z
dc.date.issued2024-11
dc.description.abstractLupus nephritis (LN) is a significant complication of systemic lupus erythematosus (SLE), marked by kidney inflammation due to autoimmune activity, leading to proteinuria, hematuria, and potentially renal failure. Rapidly progressive glomerulonephritis (RPGN) is a rare, critical manifestation of LN characterized by a rapid decline in kidney function. This condition can lead to irreversible renal damage and is often fatal without prompt treatment. In this case, a 62-year-old man initially presented with fever, cough, and body aches, which were treated as an acute upper respiratory infection. Despite initial improvement, he developed persistent nausea, vomiting, and signs of renal dysfunction. Laboratory investigations revealed anemia, high erythrocyte sedimentation rate (ESR), electrolyte imbalances, and elevated creatinine. Imaging and endoscopy ruled out malignancy, and a differential diagnosis of multiple myeloma was excluded through plasma protein electrophoresis. Serological tests confirmed SLE, and subsequent renal biopsy revealed LN with RPGN features. Despite aggressive treatment with corticosteroids and cyclophosphamide, the patient’s condition rapidly deteriorated, leading to respiratory distress and intensive care unit (ICU) admission. He ultimately succumbed to his illness, underscoring the unpredictable and severe nature of RPGN in LN. This case highlights the importance of early diagnosis and intensive management to prevent rapid disease progression and improve patient outcomes.en_US
dc.identifier.affiliationsDepartment of Medicine, University of Science and Technology Chittagong (USTC), Chittagong, Bangladeshen_US
dc.identifier.affiliationsDepartment of Nephrology, University of Science and Technology Chittagong (USTC), Chittagong, Bangladeshen_US
dc.identifier.citationDas UK, Chowdhury EH.. Male systemic lupus erythematosus, rapidly progressive glomerulonephritis, and iatrogenic acute bone marrow failure: a case report . International Journal of Scientific Reports. 2024 Nov; 10(11): 410-413en_US
dc.identifier.issn2454-2156
dc.identifier.issn2454-2164
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246976
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber11en_US
dc.relation.volume10en_US
dc.source.urihttps://doi.org/10.18203/issn.2454-2156.IntJSciRep20243054en_US
dc.subjectLupus nephritisen_US
dc.subjectSystemic lupus erythematosusen_US
dc.subjectRapidly progressive glomerulonephritisen_US
dc.subjectRenal biopsyen_US
dc.subjectImmunosuppressive therapyen_US
dc.subjectRespiratory distressen_US
dc.titleMale systemic lupus erythematosus, rapidly progressive glomerulonephritis, and iatrogenic acute bone marrow failure: a case reporten_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijsr2024v10n11p410.pdf
Size:
171.63 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Scientific Reports