Increased frequency of chloroquine resistant P. falciparum on a rubber estate in Peninsular Malaysia during two years of systematic chloroquine treatment.

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dc.contributor.authorDondero, T Jen_US
dc.contributor.authorParsons, R Een_US
dc.contributor.authorO'Holohan, D Ren_US
dc.date.accessioned2009-05-27T16:16:33Z
dc.date.available2009-05-27T16:16:33Z
dc.date.issued1975-12-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractChloroquine pressure was applied over a 22 month period on a somewhat isolated, malarious rubber estate by examination of residents at 4-week intervals and treatment of parasitaemias with chloroquine. During this time the monthly attack rate for P. falciparum rose four-fold to an average of nearly 18% per month, while that of P. vivax remained relatively constant at about 8%. Eight in vivo chloroquine resistance studies, which allowed both detection of late recrudescing R-I resistance and estimation of the risk of reinfection, showed an apparent rise in the drug resistance rate, from 12% to 20% prior to the study to the range of 40-50%. Virtually all resistance encountered was R-I in nature. There was no convincing evidence of chloroquine resistance among 148 tested P. vivax infections.en_US
dc.identifier.citationDondero TJ, Parsons RE, O'Holohan DR. Increased frequency of chloroquine resistant P. falciparum on a rubber estate in Peninsular Malaysia during two years of systematic chloroquine treatment. The Southeast Asian Journal of Tropical Medicine and Public Health. 1975 Dec; 6(4): 488-94en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34831
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshBlood --parasitologyen_US
dc.subject.meshChloroquine --pharmacologyen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshHumansen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMalaria --drug therapyen_US
dc.subject.meshMalaysiaen_US
dc.subject.meshPlasmodium falciparum --drug effectsen_US
dc.subject.meshR Factorsen_US
dc.subject.meshRecurrenceen_US
dc.titleIncreased frequency of chloroquine resistant P. falciparum on a rubber estate in Peninsular Malaysia during two years of systematic chloroquine treatment.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
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