Microbicides: a new hope for HIV prevention.

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dc.contributor.authorNutan
dc.contributor.authorGupta, Satish K
dc.date.accessioned2012-03-27T10:10:52Z
dc.date.available2012-03-27T10:10:52Z
dc.date.issued2011-12
dc.description.abstractHuman immunodeficiency virus (HIV), causative agent of acquired immunodeficiency syndrome (AIDS), is a global health concern. To control its transmission, safe sex has been proposed as one of the strategies. Microbicides- intravaginal/intrarectal topical formulations of anti-HIV agents have also been proposed to prevent HIV transmission. Microbicides would provide protection by directly inactivating HIV or preventing the attachment, entry or replication of HIV in susceptible target cells as well as their dissemination from target cells present in semen or the host cells lining the vaginal/rectal wall to other migratory cells. Microbicides must be safe, effective following vaginal or rectal administration, and should cause minimal or no genital symptoms or inflammations following long-term repeated usage. However, a safe and efficacious anti-HIV microbicide is not yet available despite the fact that more than 60 candidate agents have been identified to have in vitro activity against HIV, several of which have advanced to clinical testing. Nonetheless, proof-of-concept of microbicides has been established based on the results of recent CAPRISA 004 clinical trials. In this article, the trends and challenges in the development of effective and safe microbicides to combat HIV transmission are reviewed.en_US
dc.identifier.citationNutan, Gupta Satish K. Microbicides: a new hope for HIV prevention. Indian Journal of Medical Research. 2011 Dec; 134(6): 939-949.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/137354
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284102/en_US
dc.subjectHIVen_US
dc.subjectintravaginalen_US
dc.subjectmicrobicidesen_US
dc.subjectpreventionen_US
dc.subject.meshAdministration, Intravaginal
dc.subject.meshAnti-HIV Agents --administration & dosage
dc.subject.meshAnti-HIV Agents --pharmacology
dc.subject.meshAnti-Infective Agents, Local --administration & dosage
dc.subject.meshAnti-Infective Agents, Local --pharmacology
dc.subject.meshDrug Discovery --trends
dc.subject.meshFemale
dc.subject.meshHIV Infections --prevention & control
dc.subject.meshHIV Infections --transmission
dc.subject.meshHIV-1 --drug effects
dc.subject.meshHumans
dc.subject.meshVirus Integration --drug effects
dc.subject.meshVirus Internalization --drug effects
dc.titleMicrobicides: a new hope for HIV prevention.en_US
dc.typeArticleen_US
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