Prevention of post operative pain after abdominal hysterectomy by single dose etoricoxib.

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dc.contributor.authorChau-in, Warapornen_US
dc.contributor.authorThienthong, Somboonen_US
dc.contributor.authorPulnitiporn, Aksornen_US
dc.contributor.authorTantanatewin, Wattanaen_US
dc.contributor.authorPrasertcharoensuk, Witoonen_US
dc.contributor.authorSriraj, Wimonraten_US
dc.date.accessioned2009-05-27T19:17:47Z
dc.date.available2009-05-27T19:17:47Z
dc.date.issued2008-01-05en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To test whether a reduction in post operative morphine consumption could be achieved by a single-dose of etoricoxib before induction of anesthesia. DESIGN: Randomized, double-blind, placebo-controlled study. MATERIAL AND METHOD: Two hours before surgery, patients undergoing transabdominal hysterectomy (under general anesthesia) were randomized to a single oral dose of 1) etoricoxib 120 mg (n = 17), 2) etoricoxib 180 mg (n = 17), or 3) placebo (n = 15). Intravenous morphine was given for patient-controlled analgesia (PCA) device. Morphine consumption, pain scores both at rest and on coughing, and side-effects were recorded at 1, 2, 4, 8 and 24 h after surgery. Patients' global evaluation of study medication was assessed at the end of the present study. RESULTS: Etoricoxib provided greater clinical benefit than the placebo in terms of mean morphine in milligram at 24 hour consumption (stardard deviation): a) 26.4 mg (SD of 11.2) for etoricoxib 120 mg; b) 27.2 mg (SD of 9.9) for etoricoxib 180 mg; and, c) 36.6 mg (SD of 8.9) for the placebo group. At 8 h post surgery, pain both at rest and on coughing in the active drug groups was significantly less than in the placebo, while pain on coughing was significantly less at 24 h. Patients reported better global satisfaction and less somnolence in the etoricoxib groups. CONCLUSION: Single dose etoricoxib 180 mg given before surgery provides the same analgesic effect as 120 mg for post operative pain after an abdominal hysterectomy.en_US
dc.description.affiliationDepartment of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. warcha@kku.ac.then_US
dc.identifier.citationChau-in W, Thienthong S, Pulnitiporn A, Tantanatewin W, Prasertcharoensuk W, Sriraj W. Prevention of post operative pain after abdominal hysterectomy by single dose etoricoxib. Journal of the Medical Association of Thailand. 2008 Jan; 91(1): 68-73en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40850
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshCyclooxygenase 2 Inhibitors --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHysterectomy --adverse effectsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMorphine --administration & dosageen_US
dc.subject.meshPain Measurementen_US
dc.subject.meshPain, Postoperative --drug therapyen_US
dc.subject.meshPostoperative Perioden_US
dc.subject.meshPyridines --administration & dosageen_US
dc.subject.meshSulfones --administration & dosageen_US
dc.titlePrevention of post operative pain after abdominal hysterectomy by single dose etoricoxib.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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