Complex coronary intervention outcomes: real world left main coronary artery angioplasty experience from a tertiary care center in South India

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dc.contributor.authorSreekumar, Pradeepen_US
dc.contributor.authorPisharody, Sunilen_US
dc.contributor.authorRetnakaran, Rajagopalen_US
dc.contributor.authorIndani, Ashishen_US
dc.contributor.authorBhutada, Poonamen_US
dc.contributor.authorC., Somanathanen_US
dc.date.accessioned2020-04-09T07:42:27Z
dc.date.available2020-04-09T07:42:27Z
dc.date.issued2019-07
dc.description.abstractBackground: Left Main Coronary Artery (LMCA) Disease is among the most complex forms of the coronary artery stenosis, the leading cause of mortality in the world.Methods: In this analysis, 102 patients with elective angioplasty for LMCA stenosis with PCI from 6/2013 to 5/2016, 3 years (70 in GenxSync™ arm and 32 in other devices arm; 100 DES and 2 BMS) were included. RADHIKa Analysis compared post-hoc subgroups of GenxSync™ and control groups.Results: Mean population age was 59.99±12.03 years; 60.27±10.49 years in GenxSync™ arm, and 58.31±14.32 years in control arm. A significant population (44, 43.14%) had diabetes, renal impairment (14, 13.73%) and hypertension (25, 24.51%). The MACCE in GenxSync™ arm was 17 13(18.58%) Versus 5(15.63%) [RR=0.93, RR’=-0.07, ?=-14.01. p=0.3). Most patients presented with unstable Angina (41, 40.20%) in all, 31(44.29%) in GenxSync™ and 10 (31.25%) in Control arm. AWMI and IWMI were 18, 17.65% each, attributed to 12 (17.14%) in GenxSync™ 6 (18.75%) in Control. Effort angina was 15(21.43%) in GenxSync™ and 10 (31.25%) in Control and NSTEMI was 25,24.51% (18 (25.71%)- GenxSync™ 7(21.88%) Control). The MACE in GenxSync™ arm at 24, 12 and 6 months was 12(17.15%), 8(11.43%) and 4(5.71%) respectively versus corresponding MACE in the control arm as 5(15.63%), 2(2.86%) and 2(6.25%) respectively. The TVR was present only in GenxSync™ Arm, which was contributed by 2 CABGs and 12 months and 1 additional PCI at 24 months.Conclusions: In real-world scenario of LMCA cases, performance and safety of various stents were similar. GenxSync™ Sirolimus Eluting Stent, in the post-hoc bifurcation had results similar to other real-world cases, based upon RADHIKa analysis.en_US
dc.identifier.affiliationsDepartment of Cardiology, EMS Memorial Co-operative Hospital and Research Center Ltd., Perintalmanna, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, EMS Memorial Co-operative Hospital and Research Center Ltd., Perintalmanna, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, EMS Memorial Co-operative Hospital and Research Center Ltd., Perintalmanna, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Life Sciences Platforms, Tata Consultancy Services Ltd. Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Research Methodology, Krishnamugdha Institute of Advanced Learning and Research, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, EMS Memorial Co-operative Hospital and Research Center Ltd., Perintalmanna, Kerala, Indiaen_US
dc.identifier.citationSreekumar Pradeep, Pisharody Sunil, Retnakaran Rajagopal, Indani Ashish, Bhutada Poonam, C. Somanathan. Complex coronary intervention outcomes: real world left main coronary artery angioplasty experience from a tertiary care center in South India. International Journal of Advances in Medicine. 2019 Jul; 6(4): 1164-1170en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194369
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20193264en_US
dc.subjectComplex angioplastyen_US
dc.subjectComplex PCIen_US
dc.subjectDrug eluting stenten_US
dc.subjectGenxSyncen_US
dc.subjectleft main angioplastyen_US
dc.subjectLeft main coronary artery stenosisen_US
dc.subjectLMCA stenosisen_US
dc.titleComplex coronary intervention outcomes: real world left main coronary artery angioplasty experience from a tertiary care center in South Indiaen_US
dc.typeJournal Articleen_US
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