Imaging of CNS Infections with Clinico-pathological Correlation

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dc.contributor.authorOjha, Mandaveeen_US
dc.contributor.authorVerma, Sameer R.en_US
dc.contributor.authorSaran, Sonalen_US
dc.contributor.authorMital, Muktaen_US
dc.contributor.authorBansal, Pradeepen_US
dc.date.accessioned2020-09-24T07:10:02Z
dc.date.available2020-09-24T07:10:02Z
dc.date.issued2019-05
dc.description.abstractIntroduction: CNS infections are an emerging health problemwith poor prognosis if the treatment is not prompt andadequate. Thus, establishing a correct diagnosis is necessaryto quickly start the appropriate treatment. This study wasundertaken to study the etiology and the imaging spectrum ofCNSI in and around western Uttar Pradesh in a tertiary healthcare set up and to correlate the neuro-imaging findings withclinic-pathological data.Material and Methods: In this Prospective Observationalstudy 80 patients clinically suspected of CNS infection werestudied by CT/MRI and the neuro imaging findings werecorrelated with clinical and CSF findings.Results: Based on clinical features, CSF findings, thetreatment given and the response to treatment tuberculousinfection (TBM) was most common infection (41.2%)followed by pyogenic meningitis (36.2%) and viral infection(22.5%). In 29 patients of pyogenic CNS infection mostcommon imaging finding was leptomeningitis(62%)followed by pachymeningitis (31%), hydrocephalus (24.1%),abscess (6.8%), post vasculitic infarct(6.8%) and extra axialcollection(6.8%). In 33 patients of tubercular CNS infectionmost common imaging finding was basal leptomeningitis(78.7%) followed by tuberculoma (72.7%), pachymeningitis(33.3%), hydrocephalus (27.2%), abscess (12.1%), postvasculitis infarct (12.1%) and spinal cord involvement in1 (3%) patient. In the 18 viral CNS infection cases mostcommon imaging finding was parenchymal hyperintensity onMRI or hypodensity on CT with/without peripheral vasogenicedema (94.4%) followed by leptomeningeal/pachymeningealinvolvement (61.1%) and post vasculitis infarct (11.1%).Conclusion: The sensitivity of neuroimaging in pyogenicCNS infection was 81.2% and specificity was 93.7% whilesensitivity of neuroimaging in tubercular CNS infection was88.8% and specificity was 97.8% and in viral CNS infectionsensitivity was 84.2% and specificity was 96.7%. There wassignificant association (p value <0.05) of basal leptomeningitisand granulomas on imaging with tubercular infection andparenchymal signal changes with viral infectionsen_US
dc.identifier.affiliationsPG Student, Department of Radiodiagnsosis, SMC, Meeruten_US
dc.identifier.affiliationsProfessor, Department of Radiodiagnsosis, SMC, Meeruten_US
dc.identifier.affiliationsAssistant Professor, Department of Radiodiagnsosis, SMC, Meeruten_US
dc.identifier.affiliationsProfessor, Department of Radiodiagnsosis, SMC, Meeruten_US
dc.identifier.affiliationsAssociate Professor, Department of Radiodiagnsosis, SMC, Meerut, Indiaen_US
dc.identifier.citationOjha Mandavee, Verma Sameer R., Saran Sonal, Mital Mukta, Bansal Pradeep. Role of Magnetic Resonance Cholangiopancreatography (MRCP) in the Evaluation of Patients with Obstructive Jaundice. International Journal of Contemporary Medical Research . 2019 May; 6(5): e6-e10en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/202377
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber5en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.21276/ijcmr.2019.6.5.23en_US
dc.subjectImagingen_US
dc.subjectCNS Infectionsen_US
dc.subjectClinico-pathological Correlationen_US
dc.titleImaging of CNS Infections with Clinico-pathological Correlationen_US
dc.typeJournal Articleen_US
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