Efficacy and Safety of Intravenous Immunoglobulin (IVIg) in Acute Viral Myocarditis in Children: A Systematic Review of Randomized Controlled Trials

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dc.contributor.authorJain, Lovelyen_US
dc.contributor.authorKaur, Davinderen_US
dc.contributor.authorKhalil, Sumairaen_US
dc.contributor.authorPradhan, Pranitaen_US
dc.contributor.authorMalik, Meenakshien_US
dc.contributor.authorDogra, Saritaen_US
dc.contributor.authorKaur, Kulbiren_US
dc.contributor.authorMathew, Joseph Len_US
dc.date.accessioned2025-08-13T09:09:42Z
dc.date.available2025-08-13T09:09:42Z
dc.date.issued2025-01
dc.description.abstractCONTEXT Acute myocarditis is a rare but potentially life-threatening condi?on in infants and children. While immunosuppressive agents have shown limited effec?veness, intravenous immunoglobulin (IVIg) holds promise as a treatment op?on. OBJECTIVE To study the efficacy and safety of intravenous immunoglobulin (IVIg) in trea?ng acute viral myocardi?s in children. EVIDENCE ACQUISITION We searched five databases including PubMed, EMBASE, the Cochrane Library, Scopus, and Web of Science; and four trial registries for published studies on the topic. Grey literature was searched through ProQuest and Open Grey databases. The studies eligible for this review were randomized controlled trials in children (< 18 years) with acute viral myocardi?s (Popula?on), comparing IVIg (Interven?on), versus no IVIg i.e., any other treatment or placebo (Comparator), for efficacy and safety (Outcomes). RESULTS The literature search iden?fied a total of 9,524 records. Two reviewers independently screened these records. A total of 73 cita?ons were deemed poten?ally eligible, all of which were non-RCTs or review ar?cles on full text examina?on. There were no RCTs iden?fied to address the review ques?on. CONCLUSION There are no RCTs in children comparing the efficacy and safety of IVIg treatment in acute viral myocardi?s. Prospec?ve randomized trials are urgently required.en_US
dc.identifier.affiliationsIndian Council of Medical Research (ICMR) Advanced Centre for Evidence Based Child Health (ACEBCH)en_US
dc.identifier.affiliationsIndian Council of Medical Research (ICMR) Advanced Centre for Evidence Based Child Health (ACEBCH)en_US
dc.identifier.affiliationsDepartment of Pediatrics, University College of Medical Sciences, Delhi, Indiaen_US
dc.identifier.affiliationsIndian Council of Medical Research (ICMR) Advanced Centre for Evidence Based Child Health (ACEBCH)en_US
dc.identifier.affiliationsIndian Council of Medical Research (ICMR) Advanced Centre for Evidence Based Child Health (ACEBCH)en_US
dc.identifier.affiliationsIndian Council of Medical Research (ICMR) Advanced Centre for Evidence Based Child Health (ACEBCH)en_US
dc.identifier.affiliationsIndian Council of Medical Research (ICMR) Advanced Centre for Evidence Based Child Health (ACEBCH)en_US
dc.identifier.affiliationsIndian Council of Medical Research (ICMR) Advanced Centre for Evidence Based Child Health (ACEBCH); Department of Pediatrics, Postgraduate Ins?tute of Medical Education and Research (PGIMER), Chandigarh, Indiaen_US
dc.identifier.citationJain Lovely, Kaur Davinder, Khalil Sumaira, Pradhan Pranita, Malik Meenakshi, Dogra Sarita, Kaur Kulbir, Mathew Joseph L. Efficacy and Safety of Intravenous Immunoglobulin (IVIg) in Acute Viral Myocarditis in Children: A Systematic Review of Randomized Controlled Trials. Indian Pediatrics. 2025 Jan; 62(1): 56-62en_US
dc.identifier.issn0019-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/251357
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber1en_US
dc.relation.volume62en_US
dc.source.urihttps://indianpediatrics.net/jan2025/56.pdfen_US
dc.subjectCardiacen_US
dc.subjectImmunosuppressionen_US
dc.subjectPediatricsen_US
dc.subjectSystematic reviewen_US
dc.titleEfficacy and Safety of Intravenous Immunoglobulin (IVIg) in Acute Viral Myocarditis in Children: A Systematic Review of Randomized Controlled Trialsen_US
dc.typeJournal Articleen_US
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