Histological and immunohistochemical features in fatal acute fulminant hepatitis E.

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dc.contributor.authorAgrawal, Vinita
dc.contributor.authorGoel, Amit
dc.contributor.authorRawat, Amit
dc.contributor.authorNaik, Sita
dc.contributor.authorAggarwal, Rakesh
dc.date.accessioned2012-10-16T03:56:37Z
dc.date.available2012-10-16T03:56:37Z
dc.date.issued2012-01
dc.description.abstractBackground: Hepatitis E is being increasingly recognized as an emerging infection in developed countries. Data on histological findings and nature of inflammatory cell infiltrate in liver in this disease are quite sparse. Aims: This study was planned to study the histological features and the type of inflammatory infiltrate in liver biopsies of patients with acute fulminant hepatitis E. Materials and Methods: We retrieved postmortem liver biopsies of 11 Indian patients with fulminant hepatitis E, and compared these with biopsies from seven patients with fulminant hepatitis B. Results : Biopsies from acute fulminant hepatitis E showed varying degrees of hepatocyte necrosis, mixed portal and lobular inflammation, accompanied by bile ductular proliferation, lymphocytic cholangitis, Kupffer cell prominence, cholestasis, apoptotic bodies, pseudo-rosette formation, steatosis, and presence of plasma cells in portal tracts. Interface hepatitis was more frequent in acute hepatitis B than in acute hepatitis E (100% vs 20%; P<0.05). These findings differ from those reported in cases with autochthonous hepatitis E in Europe. On immunohistochemistry, lymphocyte infiltrate consisted predominantly of CD3 + T cells in both hepatitis E and hepatitis B; these cells contained a predominant cytotoxic (CD8 + ) cell subpopulation in 81.8% of cases with hepatitis E and in 50% of cases with hepatitis B. Conclusion: Our findings suggest that histological changes in HEV infection may vary with geographical location because of prevalent HEV genotypes, and that CD8 + lymphocytes play a role in HEV-induced liver injury.en_US
dc.identifier.citationAgrawal Vinita, Goel Amit, Rawat Amit, Naik Sita, Aggarwal Rakesh. Histological and immunohistochemical features in fatal acute fulminant hepatitis E. Indian Journal of Pathology & Microbiology. 2012 Jan-Mar 55(1): 22-27.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142170
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=1;spage=22;epage=27;aulast=Agrawalen_US
dc.subjectAcute hepatitis Een_US
dc.subjectacute hepatitis Ben_US
dc.subjectimmunohistochemistryen_US
dc.subjectliver histologyen_US
dc.subjectT lymphocytesen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAntigens, CD3 --analysis
dc.subject.meshBiopsy
dc.subject.meshCD8-Positive T-Lymphocytes --immunology
dc.subject.meshChild
dc.subject.meshFemale
dc.subject.meshHepatitis B --pathology
dc.subject.meshHepatitis E --pathology
dc.subject.meshHistocytochemistry
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshLiver --pathology
dc.subject.meshMale
dc.subject.meshMicroscopy
dc.subject.meshMiddle Aged
dc.subject.meshYoung Adult
dc.titleHistological and immunohistochemical features in fatal acute fulminant hepatitis E.en_US
dc.typeArticleen_US
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