Genome inventory and analysis of nuclear hormone receptors in Tetraodon nigroviridis.

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dc.contributor.authorMetpally, Raghu Prasad Raoen_US
dc.contributor.authorVigneshwar, Ramakrishnanen_US
dc.contributor.authorSowdhamini, Ramanathanen_US
dc.date.accessioned2007-01-12en_US
dc.date.accessioned2009-06-01T14:15:07Z
dc.date.available2007-01-12en_US
dc.date.available2009-06-01T14:15:07Z
dc.date.issued2007-01-12en_US
dc.description.abstractNuclear hormone receptors (NRs) form a large superfamily of ligand-activated transcription factors, which regulate genes underlying a wide range of (patho) physiological phenomena. Availability of the full genome sequence of Tetraodon nigroviridis facilitated a genome wide analysis of the NRs in fish genome. Seventy one NRs were found in Tetraodon and were compared with mammalian and fish NR family members. In general, there is a higher representation of NRs in fish genomes compared to mammalian ones. They showed high diversity across classes as observed by phylogenetic analysis. Nucleotide substitution rates show strong negative selection among fish NRs except for pregnane x receptor (PxR), estrogen receptor (ER) and liver x receptor (LxR). This may be attributed to crucial role played by them in metabolism and detoxification of xenobiotic and endobiotic compounds and might have resulted in slight positive selection. Chromosomal mapping and pairwise comparisons of NR distribution in Tetraodon and humans led to the identification of nine syntenic NR regions, of which three are common among fully sequenced vertebrate genomes. Gene structure analysis shows strong conservation of exon structures among orthologoues. Whereas paralogous members show different splicing patterns with intron gain or loss and addition or substitution of exons played a major role in evolution of NR superfamily.en_US
dc.description.affiliationNational Centre for Biological Sciences, Tata Institute of Fundamental Research, UAS-GKVK Campus, Bellary Road, Bangalore 560 065, India.en_US
dc.identifier.citationMetpally RP, Vigneshwar R, Sowdhamini R. Genome inventory and analysis of nuclear hormone receptors in Tetraodon nigroviridis. Journal of Biosciences. 2007 Jan; 32(1): 43-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110696
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAlternative Splicingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshExonsen_US
dc.subject.meshGenomeen_US
dc.subject.meshHumansen_US
dc.subject.meshIntronsen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshProtein Structure, Tertiaryen_US
dc.subject.meshReceptors, Cytoplasmic and Nuclear --chemistryen_US
dc.subject.meshSyntenyen_US
dc.subject.meshTetraodontiformes --geneticsen_US
dc.titleGenome inventory and analysis of nuclear hormone receptors in Tetraodon nigroviridis.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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