Ni2+-uptake in Pseudomonas putida strain S4: a possible role of Mg2+-uptake pump.

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dc.contributor.authorTripathi, V Nen_US
dc.contributor.authorSrivastava, Sen_US
dc.date.accessioned2006-03-06en_US
dc.date.accessioned2009-06-01T14:54:36Z
dc.date.available2006-03-06en_US
dc.date.available2009-06-01T14:54:36Z
dc.date.issued2006-03-06en_US
dc.description.abstractEssential metal ion homeostasis is based on regulated uptake of metal ions, both during its scarcity and abundance. Pseudomonas putida strain S4, a multimetal resistant bacterium, was employed to investigate Ni(2+) entry into cells. It was observed that Mg(2+) regulates the entry of Ni(2+) and by this plays a protective role to minimize Ni(2+) toxicity in this strain. This protection was evident in both growth as well as viability. Intracellular accumulation of Ni(2+) varied in accordance with Mg(2+) concentrations in the medium. It was hypothesized that Ni(2+) enters the cell using a broad Mg(2+) pump, i.e. the CorA system, as the CorA inhibitor, i.e. Co(III) Hex, also inhibits Ni 2+ uptake. This led to the inference that Mg(2+)-based protection was basically due to competitive inhibition of Ni(2+) uptake. We also show that Zn(2+) can further regulate the entry of Ni(2+).en_US
dc.description.affiliationDepartment of Genetics, University of Delhi, South Campus, New Delhi, India.en_US
dc.identifier.citationTripathi VN, Srivastava S. Ni2+-uptake in Pseudomonas putida strain S4: a possible role of Mg2+-uptake pump. Journal of Biosciences. 2006 Mar; 31(1): 61-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111165
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshCation Transport Proteins --antagonists & inhibitorsen_US
dc.subject.meshCobalt --pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshIon Transporten_US
dc.subject.meshMagnesium --metabolismen_US
dc.subject.meshNickel --metabolismen_US
dc.subject.meshPseudomonas putida --classificationen_US
dc.subject.meshZinc --metabolismen_US
dc.titleNi2+-uptake in Pseudomonas putida strain S4: a possible role of Mg2+-uptake pump.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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