Tapasin expression in cervical carcinoma

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dc.contributor.authorPatcharee Jearanaikoonen_US
dc.contributor.authorNichapawee Nattasirikulen_US
dc.contributor.authorWipawee Kaewpoen_US
dc.contributor.authorSurasak Wanramen_US
dc.contributor.authorChanvit Leelayuwaten_US
dc.contributor.authorAnucha Paupairojen_US
dc.contributor.authorTemduang Limpaiboonen_US
dc.date.accessioned2011-02-20T04:32:56Z
dc.date.available2011-02-20T04:32:56Z
dc.date.created2010-01-20en_US
dc.date.issued2010-01-20en_US
dc.description.abstractCervical cancer is the most common cancer among women worldwide. Even though HPV infection is known as the major risk factor of cervical carcinogenesis, immune evasion of infected cells or tumor cells is also well established as the major contributing factors. Down regulation of MHC class I as well as the presence of non-surface presenting MHC class I molecules have been previously reported. Our aim of this study is to investigate the expression level of tapasin protein which is one of the MHC class I antigen processing proteins in various stages of cancerous tissues. Seventy nine dysplasia and 49 cases of cervical cancer and 49 normal cervix from myoma patients as control were included in this study. The association between the expression level and disease progression was analyzed using χ2 for trend. The reduction of tapasin expression is significantly associated with respect to the progression of staging in both dysplasia and cervical cancer group (p=0.001; χ2 for trend). In conclusion, our study illustrates that the reduction in tapasin expression might exert as one of the mechanism leading to the impairment of antigen presenting of MHC class I in cancerous tissues. Therefore, tapasin staining might be useful as an early prognostic marker in dysplasia. More antigen processing proteins should be also further investigated.en_US
dc.identifier.citationJournal of Medical Technology and Physical Therapy; Volume 19 Number 1, January - April 2007en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/130865
dc.language.isoen_USen_US
dc.publisherKhon Kaen Universityen_US
dc.rightsKhon Kaen Universityen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/JMTPT/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/JMTPT/article/view/587en_US
dc.titleTapasin expression in cervical carcinomaen_US
dc.typeORIGINAL ARTICLEen_US
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