Drug Resistant Mycobacterium Tuberculosis in New Cases in Maharat Nakhon Ratchasima Hospital in 2007
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Date
2010-03-14
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Royal Thai Airforce Medical Gazette
Abstract
BACKGROUND: Standard anti-tuberculosis regimen is usually effective in drug sensitive cases of tuberculosis. On contrary, it may possible fail in cases of drug resistance (MDR-TB). In 1998, 2002, MDR-TB is rarely found, routine culture and sensitivity test are not recommended. OBJECTIVE: To verify the incidence of drug resistance in new cases of pulmonary tuberculosis and study the risk factors. METHOD: All smear positive pulmonary tuberculosis patients in 2007 were recruited. History taking and sputum culture with sensitivity test were performed. Anti-HIV test was recommended in all cases. RESULT: Sputum culture for M.tuberculosis were performed in 161 patients who had positive AFB in sputum. 132 were newly treated while 29 were previously treated. For new cases the culture were yielded in 86 cases, 7 case were INH single drug resistant, whereas one of them was HIV positive, and 7 cases were MDR-TB and only 1 case was HIV positive. For previously treated cases culture were yielded in 22 cases, 6 were MDR-TB, 2 of them were HIV positive. MDR-TB in previously treated were higher than newly treated cases (OR=4.23, 95% CI=1.25-14.27) and did not related to HIV infection. CONCLUSION: We founded 8.1% INH single drug resistance in new cases and did not related to HIV infection. MDR-TB was founded 8.1% in new cases did not related to HIV infection too. In previously treated cases we founded MDR-TB 27.3% which is more than newly treated cases.
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Royal Thai Airforce Medical Gazette; Vol.54 No.1 January-April 2008; 30