In vitro susceptibility of clinical isolates of Mycobacterium tuberculosis to cefadroxil--a cephalosporin antibiotic.

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dc.contributor.authorSelvakumar, Nen_US
dc.contributor.authorKumar, Ven_US
dc.contributor.authorParamasivan, C Nen_US
dc.date.accessioned1997-02-01en_US
dc.date.accessioned2009-05-27T07:25:28Z
dc.date.available1997-02-01en_US
dc.date.available2009-05-27T07:25:28Z
dc.date.issued1997-02-01en_US
dc.description.abstractThe bactericidal activity (BA) of cefadroxil, a semisynthetic cephalosporin antibiotic, against M. tuberculosis H37Rv was studied in Middlebrook 7H9 medium. Cefadroxil showed good BA (average fall of viable counts = log10 0.32 colony forming units/ml/day) against the log phase culture of M. tuberculosis H37Rv. Its minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were found to be 15 micrograms/ml or less. The MIC of cefadroxil for 29 clinical isolates of M. tuberculosis and a laboratory strain, M. tuberculosis H37Rv was also determined by agar dilution method using Middlebrook 7H11 agar as a screening procedure. The MIC of cefadroxil was found to be 10 micrograms/ml or less for M. tuberculosis H37Rv and 16 (55.1%) of 29 clinical isolates tested. The MIC for 3 of 10 drug sensitive and 9 of 19 drug resistant isolates was 40 or more, a concentration much higher than the peak plasma concentration (28 micrograms/ml) attained in human beings. The higher MIC observed in 12 of 29 clinical isolates irrespective of their susceptibility pattern requires further studies to assess the usefulness of cefadroxil in the treatment of tuberculosis.en_US
dc.description.affiliationTuberculosis Research Centre (ICMR), Chennai.en_US
dc.identifier.citationSelvakumar N, Kumar V, Paramasivan CN. In vitro susceptibility of clinical isolates of Mycobacterium tuberculosis to cefadroxil--a cephalosporin antibiotic. Indian Journal of Medical Research. 1997 Feb; 105(): 58-60en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/20649
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshCefadroxil --pharmacologyen_US
dc.subject.meshCephalosporins --pharmacologyen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshHumansen_US
dc.subject.meshMycobacterium tuberculosis --drug effectsen_US
dc.titleIn vitro susceptibility of clinical isolates of Mycobacterium tuberculosis to cefadroxil--a cephalosporin antibiotic.en_US
dc.typeJournal Articleen_US
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