Ganjam virus.
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Date
2009-11
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Abstract
Ganjam virus (GANV), a member of genus Nairovirus of family Bunyavirdae is of considerable veterinary
importance in India. Though, predominantly tick borne, GANV was also isolated from mosquitoes, man
and sheep. Neutralizing and complement fixing antibodies to GANV have been detected in animal and
human sera collected from different parts of the country. Thirty three strains of GANV have been isolated
from India, mainly from Haemaphysalis ticks. The virus replicated in certain vertebrate and mosquito
cell lines and found pathogenic to laboratory animals. One natural infection and five laboratoryacquired
infections in men were also reported. GANV is antigenically related to Nairobi sheep disease
virus (NSDV) of Africa, which is highly pathogenic for sheep and goats causing 70-90 per cent mortality
among the susceptible population. Recent molecular studies have demonstrated that GANV is an Asian
variant of NSDV and both these viruses are related to the dreaded Crimean Congo haemorrhagic fever
(CCHF) group viruses. The versatility of the virus to replicate in different arthropod species, its ability to infect sheep, goat and man makes it an important zoonotic agent.
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Keywords
Ganjam virus, Haemaphysalis intermedia, Nairobi sheep disease, Nairovirus, tick
Citation
Sudeep A B, Jadi R S, Mishra A C. Ganjam virus. Indian Journal of Medical Research. 2009 Nov; 130(5): 514-519.