The effect of montelukast on bronchial hyperreactivity and lung function in asthmatic children aged 6-13 years.

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dc.contributor.authorVisitsunthorn, Nualanong
dc.contributor.authorChirdjirapong, Varakorn
dc.contributor.authorSantadilog, Satit
dc.contributor.authorPajarn, Panjama
dc.contributor.authorJirapongsananuruk, Orathai
dc.contributor.authorKomoltri, Chulaluk
dc.contributor.authorVichyanond, Pakit
dc.date.accessioned2012-01-12T04:11:29Z
dc.date.available2012-01-12T04:11:29Z
dc.date.issued2011-06
dc.description.abstractBackground: Cysteinyl leukotrienes have been shown to play an important role in the pathogenesis of asthma. The effect of the leukotriene receptor antagonist, montelukast, on bronchial hyperreactivity (BHR) as measured by the methacholine challenge test in school children has not been reported. Objective: To determine the effect of montelukast (Singulairâ) on BHR measured by methacholine challenge and lung function tests in Thai asthmatic children aged 6-13 years. Materials and methods: This was a randomized, double-blind, placebo-controlled, crossover study performed in 29 mild to moderate persistent asthmatic children aged 6-13 years. Each child received crossover treatment with 6 weeks of montelukast (5 mg/day) and 6 weeks of placebo separated by a two-week washout period. Results: The improvement of FEV1 and FEV1/FVC after 6 weeks of treatment was significantly higher in montelukast group compared to those of placebo group (p<0.05). After 6 weeks of treatment, mean (+ SEM) PC was 20 in the placebo group (5.7 + 1.41 mg/ml) which was lower than in montelukast group (6.8 + 1.74 mg/ml) but there was no significant difference (p=0.79). Conclusion: Montelukast significantly improved FEV1 and FEV1/FVC but not BHR in mild to moderate persistent asthmatic children aged 6-13 years after the 6 weeks of treatment.en_US
dc.identifier.citationVisitsunthorn Nualanong, Chirdjirapong Varakorn, Santadilog Satit, Pajarn Panjama, Jirapongsananuruk Orathai, Komoltri Chulaluk, Vichyanond Pakit. The effect of montelukast on bronchial hyperreactivity and lung function in asthmatic children aged 6-13 years. Asian Pacific Journal of Allergy and Immunology, 2011 Jun; 29(2): 127-133.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/136406
dc.language.isoenen_US
dc.source.urihttps://apjai.digitaljournals.org/index.php/apjai/article/viewFile/414/388en_US
dc.subjectMontelukasten_US
dc.subjectasthmatic childrenen_US
dc.subjectcysteinyl leukotriene receptor antagonisten_US
dc.subjectbronchial hyperreactivityen_US
dc.titleThe effect of montelukast on bronchial hyperreactivity and lung function in asthmatic children aged 6-13 years.en_US
dc.typeArticleen_US
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