Determining the Efficacy of Centchroman in Treatment of Mastalgia
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Date
2023-04
Journal Title
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Publisher
International Research Organization for Life & Health Sciences
Abstract
Background: Breast pain or mastalgia is a common complaint among the woman presenting in surgical as well asgynecological OPD. Several non-medical and medical management has been tried for the treatment of mastalgia sinceages. In this study, we have studied role of centchroman in treatment of mastalgia and also tried to observe its side effectsand compliance.Materials and Methods: It was a prospective observational study. Seventy-eight eligible patients fulfilling the eligibility criteriawere enrolled for study. Each patient was given separate patient information sheet and proper counseling was done aboutthe study and consent was taken. Tablet centchroman was give 30 mg bi weekly for 3 months. Follow-up was done at 1, 2,and 3 months and final closure was done at 6 months. The results were observed on a daily breast pain chart improvisedby author.Results: Adaily breast pain chart was used in the study for assessment of pain. The minimum value was zero depicting no painwhile maximum value was 4 indicating breast pain at rest. At the start of study, mean pain score was 1.44 ± 1.273. After 1 month,mean pain score became 0.764 ± 0.599, which is decrease of about 47%. By the end of 2 months, it was 0.548 ± 0.601 (decreaseof 62%). It rose slightly to 0.690 ± 0.478 (approximately 20% rise in mean pain score than 2 months) level indicating that fewpatients were having recurrences. By the end of 6 months, mean pain score was 0.810 ± 0.647 indicating 43% decrease inmean pain score with respect to pain at beginning of the study. The side effects encountered in this study were mostly menstrualrelated which were temporary and normal menses were resumed on stopping medication.Conclusion: This study shows that centchroman is a very effective drug for treatment of mastalgia with minimal and less severeside effects. It also shows less recurrence and patient is more compliant due to easy dosage.
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Keywords
Mastalgia, Cyclical, Non-cyclical, SERM, Centchroman
Citation
Najim M, Mukhopadhyay B, Islam MS, Singh AK, Sasmal A. Determining the Efficacy of Centchroman in Treatment of Mastalgia. International Journal of Scientific Study. 2023 Apr; 11(1): 26-33