Pathology in children of HIV women.

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dc.contributor.authorNso, A P
dc.contributor.authorGarcía-Bermejo, C
dc.contributor.authorLarru, B
dc.contributor.authorMadero, R
dc.contributor.authorMuñoz Fernández, M A
dc.contributor.authorde José, M I
dc.date.accessioned2012-10-25T04:02:22Z
dc.date.available2012-10-25T04:02:22Z
dc.date.issued2009-11
dc.description.abstractObjective. To assess the frequency of perinatal pathology in children exposed to antiretrovirals in perinatal period. Methods. Retrospective observational cohort study. Data collected among uninfected children born to HIV-infected women followed up from 1994 to 2006 in a tertiary Hospital. 220 uninfected children were studied. Factors studied included maternal, obstetrical and pediatric variables. Results. The most common disorder found among children exposed to antiretroviral drugs was anemia (84%); 6,4% of children had neutropenia and more than 24% had thrombocytosis, a finding never described before. Prematurity (24%) and low birth weight (23.6%) rates were high. Several congenital malformations were found: Poland syndrome, angiomas, hypospadias, Pierre-Robin sequence, trisomy 8, craniostosis and others. Long-term follow-up revealed neurological, cardiological and ophthalmological pathologies. Conclusion. Some pathologies are frequent among children exposed to antiretroviral agents during perinatal life. It is crucial to carry out long-term studies to assess the safety of this therapy.en_US
dc.identifier.citationNso A P, García-Bermejo C, Larru B, Madero R, Muñoz Fernández M A, de José M I. Pathology in children of HIV women. Indian Journal of Pediatrics. 2009 Nov; 76(11): 1125-1130.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142422
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/icb/t09/i11/icbt09i11p1125.pdfen_US
dc.subjectAIDSen_US
dc.subjectPregnancyen_US
dc.subjectAntiretroviral treatmenten_US
dc.subjectAdverse effectsen_US
dc.subjectPerinatal pathologyen_US
dc.subject.meshAbnormalities, Multiple --epidemiology
dc.subject.meshAdult
dc.subject.meshAnemia --chemically induced
dc.subject.meshAnemia --epidemiology
dc.subject.meshAnti-Retroviral Agents --therapeutic use
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHIV Infections --drug therapy
dc.subject.meshHIV Infections --epidemiology
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshNeutropenia --chemically induced
dc.subject.meshNeutropenia --epidemiology
dc.subject.meshPerinatology
dc.subject.meshPrevalence
dc.subject.meshPuerperal Disorders --epidemiology
dc.subject.meshPuerperal Disorders --etiology
dc.subject.meshRetrospective Studies
dc.subject.meshThrombocytosis --chemically induced
dc.subject.meshThrombocytosis --epidemiology
dc.titlePathology in children of HIV women.en_US
dc.typeArticleen_US
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