Netarsudil monotherapy as the initial treatment for open-angle glaucoma and ocular hypertension in Indian patients: A real-world evaluation of efficacy and safety

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dc.contributor.authorMathur, Manoj Chandraen_US
dc.contributor.authorRatnam, P. Venkaten_US
dc.contributor.authorSaikumar, S.J.en_US
dc.contributor.authorJohn, Manuelen_US
dc.contributor.authorRavishankar, Siddharthen_US
dc.contributor.authorDinesh, M.Ben_US
dc.contributor.authorChandil, Priyaen_US
dc.contributor.authorPahuja, Kishoreen_US
dc.contributor.authorCherlikar, Vidyaen_US
dc.contributor.authorWadhwani, Sunnyen_US
dc.contributor.authorBendale, Pankajen_US
dc.contributor.authorHazari, Ajiten_US
dc.contributor.authorMishra, Rajeshen_US
dc.contributor.authorDeshmukh, Susheelen_US
dc.contributor.authorAchlerkar, Rahul Rajaen_US
dc.contributor.authorShah, Devang Tilaken_US
dc.contributor.authorHingorani, Chandaen_US
dc.contributor.authorShah, Kaivanen_US
dc.contributor.authorTopiwala, Pratiken_US
dc.contributor.authorJani, Sheetalen_US
dc.contributor.authorRana, Viral G.en_US
dc.contributor.authorMajumdar, Nilay Kumaren_US
dc.contributor.authorChakrabarti, Debasisen_US
dc.contributor.authorDey, Rituparnaen_US
dc.contributor.authorHalder, Debabrataen_US
dc.contributor.authorChoudhury, Sumiten_US
dc.contributor.authorKumar, Ajeeten_US
dc.contributor.authorDas, Sasmitaen_US
dc.contributor.authorNanda, Ashok Kumaren_US
dc.contributor.authorKumar, Vidya Bhushanen_US
dc.contributor.authorDubey, Ramaen_US
dc.contributor.authorKamdar, Gulam Alien_US
dc.contributor.authorPandey, Alkaen_US
dc.contributor.authorKishanpuria, Sheetalen_US
dc.contributor.authorSrivastava, Rajat Mohanen_US
dc.contributor.authorSingh, Parulen_US
dc.contributor.authorVerma, Sunil Kumaren_US
dc.contributor.authorSharma, Nehaen_US
dc.contributor.authorGupta, Rajeeven_US
dc.date.accessioned2023-08-25T06:37:25Z
dc.date.available2023-08-25T06:37:25Z
dc.date.issued2023-06
dc.description.abstractPurpose: Glaucoma is the second leading cause of blindness worldwide, affecting more than 64 million people aged 40–80. The best way to manage primary open?angle glaucoma (POAG) is by lowering the intraocular pressure (IOP). Netarsudil is a Rho kinase inhibitor, the only class of antiglaucoma medications that reorganizes the extracellular matrix to improve the aqueous outflow through the trabecular pathway. Methods: An open?label, real?world, multicentric, observation?based 3?month study was performed for assessing the safety and ocular hypotensive efficacy of netarsudil ophthalmic solution (0.02% w/v) in patients with elevated IOP. Patients were given netarsudil ophthalmic solution (0.02% w/v) as a first?line therapy. Diurnal IOP measurements, best?corrected visual acuity, and adverse event assessments were recorded at each of the five visits (Day?1: screening day and first dosing day; subsequent observations were taken at 2 weeks, 4 weeks, 6 weeks, and 3 months). Results: Four hundred and sixty?nine patients from 39 centers throughout India completed the study. The mean IOP at baseline of the affected eyes was 24.84 ± 6.39 mmHg (mean ± standard deviation). After the first dose, the IOP was measured after 2, 4, and 6 weeks, with the final measurement taken at 3 months. The percentage reduction in IOP in glaucoma patients after 3 months of once?daily netarsudil 0.02% w/v solution use was 33.34%. The adverse effects experienced by patients were not severe in the majority of cases. Some adverse effects observed were redness, irritation, itching, and others, but only a small number of patients experienced severe reactions, as reported in a decreasing order: redness > irritation > watering > itching > stinging > blurring. Conclusion: We found that netarsudil 0.02% w/v solution monotherapy when used as the first?line treatment in primary open?angle glaucoma and ocular hypertension was both safe and effective.en_US
dc.identifier.affiliationsSwarup Eye Centre, Swarup Eye Centre, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsSarojini Devi Eye Hospital, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsGiridhar Eye Institute, Kochi, Kerala, Indiaen_US
dc.identifier.affiliationsHoly Ghost Mission Hospital, Kottayam, Kerala, Indiaen_US
dc.identifier.affiliationsDr. Ravi Shankar Eye Clinic, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsUma Eye Clinic, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsSushrutha Eye Hospital, Mysuru, Karnataka, Indiaen_US
dc.identifier.affiliationsNatasha Eye Care and Research Centre, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsH.V. Desai Hospital, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDivya Jyot Eye Care, Akola, Maharashtra, Indiaen_US
dc.identifier.affiliationsDr. Bendale’s Eye Care, Pimpri-Chinchwad, Maharashtra, Indiaen_US
dc.identifier.affiliationsHazari Nursing Home, Aurangabad, Maharashtra, Indiaen_US
dc.identifier.affiliationsAdvanced Eye Hospital, A Unit of Dr Agarwals Eye Hospital, Vashi, Navi Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsSudrishti Eye Care and Goregaon Glaucoma Centre, Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDr Raja Superspeciality Eye Hospital, Navi Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDevang Multispeciality Eye Care, Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsNuvision Eyecare and Glaucoma Centre, Maharashtra, Indiaen_US
dc.identifier.affiliationsBhavna Super Speciality Eye Care, Surat, Gujarat, Indiaen_US
dc.identifier.affiliationsSurat Cornea Care Center, Surat, Gujarat, Indiaen_US
dc.identifier.affiliationsNetralaya Superspecialty Eye Hospital, Ahmedabad, Gujarat, Indiaen_US
dc.identifier.affiliationsShree Bidada Survoday Trust- Laxmi Jyot Eye Hospital, Bidada, Gujarat, Indiaen_US
dc.identifier.affiliationsSusrut Eye Foundation and Research Centre, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsCentre For Sight, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsCitizen’s Eye and Healthcare, Hooghly, West Bengal, Indiaen_US
dc.identifier.affiliationsSecond Sight Southend Eye Centre, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsNirmaya Clinic, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsSharda Eye and Dental Hospital, Patna, Bihar, Indiaen_US
dc.identifier.affiliationsKar Vision Eye Hospital, Bhubaneshwar, Odisha, Indiaen_US
dc.identifier.affiliationsRegional Institute Of Ophthalmology, IGIMS, Patna, Bihar, Indiaen_US
dc.identifier.affiliationsRama Eye Hospital, Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDr. Kamdar Eye Hospital, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsEyeen_US
dc.identifier.affiliationsChaudhary Eye Centre, New Delhi, Indiaen_US
dc.identifier.affiliationsSharp Sight Eye Hospital, New Delhi, Indiaen_US
dc.identifier.affiliationsKing George’s Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsGSVM Medical College, Kanpur,Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsRaj Eye Hospital, Gorakhpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsP.C. Sharma Eye Hospital, Ambala, Haryana, Indiaen_US
dc.identifier.affiliationsSangam Netralya, Mohali, Punjab, Indiaen_US
dc.identifier.citationMathur Manoj Chandra, Ratnam P. Venkat, Saikumar S.J., John Manuel, Ravishankar Siddharth, Dinesh M.B, Chandil Priya, Pahuja Kishore, Cherlikar Vidya, Wadhwani Sunny, Bendale Pankaj, Hazari Ajit, Mishra Rajesh, Deshmukh Susheel, Achlerkar Rahul Raja, Shah Devang Tilak, Hingorani Chanda, Shah Kaivan, Topiwala Pratik, Jani Sheetal, Rana Viral G., Majumdar Nilay Kumar, Chakrabarti Debasis, Dey Rituparna, Halder Debabrata, Choudhury Sumit, Kumar Ajeet, Das Sasmita, Nanda Ashok Kumar, Kumar Vidya Bhushan, Dubey Rama, Kamdar Gulam Ali, Pandey Alka, Kishanpuria Sheetal, Srivastava Rajat Mohan, Singh Parul, Verma Sunil Kumar, Sharma Neha, Gupta Rajeev. Netarsudil monotherapy as the initial treatment for open-angle glaucoma and ocular hypertension in Indian patients: A real-world evaluation of efficacy and safety. Indian Journal of Ophthalmology. 2023 Jun; 71(6): 2500-2503en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225087
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber6en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_25_23en_US
dc.subjectGlaucomaen_US
dc.subjectIOPen_US
dc.subjectnetarsudilen_US
dc.subjectocular hypertensionen_US
dc.subjectRho kinase inhibitorsen_US
dc.titleNetarsudil monotherapy as the initial treatment for open-angle glaucoma and ocular hypertension in Indian patients: A real-world evaluation of efficacy and safetyen_US
dc.typeJournal Articleen_US
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