Influence of ambient temperature and drug treatments on brain oedema induced by impact injury on skull in rats.

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dc.contributor.authorDey, P Ken_US
dc.contributor.authorSharma, H Sen_US
dc.date.accessioned1984-07-01en_US
dc.date.accessioned2009-06-01T05:15:40Z
dc.date.available1984-07-01en_US
dc.date.available2009-06-01T05:15:40Z
dc.date.issued1984-07-01en_US
dc.description.abstractThe progression and persistence of oedema development following impact-injury on closed skull was studied in anaesthetised as well as in unanaesthetised rats. The degree and rate of oedema development, following trauma, was aggravated in anaesthetised hypothermic animals but was reduced/or delayed by maintenance of body temperature at euthermic level. In general, the unanaesthetised animals showed a greater accumulation of oedema fluid than the corresponding anaesthetised group. The development of oedema corresponded more or less with the accumulation of 5-HT level in plasma and brain. This development of oedema was completely prevented following pretreatment with p-CPA, indomethacin paracetamol and aminophylline in unanaesthetised animals; whereas these drugs were able only to partially reduce the oedema development in euthermic anaesthetised animals. On the other hand the cyproheptadine pretreatment aggravated the oedema development which was more pronounced in unanaesthetised animals. The probable mechanism of the action of these drugs has been discussed.en_US
dc.identifier.citationDey PK, Sharma HS. Influence of ambient temperature and drug treatments on brain oedema induced by impact injury on skull in rats. Indian Journal of Physiology and Pharmacology. 1984 Jul-Sep; 28(3): 177-86en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106477
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAcetaminophen --therapeutic useen_US
dc.subject.meshAminophylline --therapeutic useen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Edema --drug therapyen_US
dc.subject.meshCyproheptadine --adverse effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFenclonine --therapeutic useen_US
dc.subject.meshIndomethacin --therapeutic useen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshSerotonin --blooden_US
dc.subject.meshSkull --injuriesen_US
dc.subject.meshTemperatureen_US
dc.titleInfluence of ambient temperature and drug treatments on brain oedema induced by impact injury on skull in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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