Estimation of tissue DNA content in Wilm's tumour.

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dc.contributor.authorSharma, S Pen_US
dc.contributor.authorGopal, S Cen_US
dc.contributor.authorGangopadhyay, A Nen_US
dc.contributor.authorGupta, D Ken_US
dc.contributor.authorChansuria, J Pen_US
dc.date.accessioned1994-07-01en_US
dc.date.accessioned2009-05-30T14:40:43Z
dc.date.available1994-07-01en_US
dc.date.available2009-05-30T14:40:43Z
dc.date.issued1994-07-01en_US
dc.description.abstractDNA genome, is affected by malignant processes. Estimation of DNA content was carried out biochemically using Gile's and Myer's technique to assess its prognostic value in 21 cases of Wilm's tumour. The DNA content of tumour tissue and normal adjoining renal tissue was estimated in each case. The DNA content was significantly higher in Wilm's tumour tissue as compared to normal renal tissue (p < 0.05). As the disease advanced, the DNA content of the tumour further increased. The tumours having unfavourable histology had significantly higher DNA content as compared to favourable histology cases (p < 0.001). Similarly, the patients who died because of the disease, had a very high DNA content as compared to those who survived. Further, it was seen that two fold increase in DNA content indicated advanced stage (III & IV), whereas a three fold or more increase indicated grave prognosis as it was usually seen in advanced stage with unfavourable histology and such cases died early. Thus, the DNA content estimation has a prognostic significance in Wilm's tumour.en_US
dc.description.affiliationDivision of Pediatric Surgery, Banaras Hindu University, Varanasi.en_US
dc.identifier.citationSharma SP, Gopal SC, Gangopadhyay AN, Gupta DK, Chansuria JP. Estimation of tissue DNA content in Wilm's tumour. Indian Journal of Pediatrics. 1994 Jul-Aug; 61(4): 347-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/82886
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDNA --analysisen_US
dc.subject.meshDNA, Neoplasm --analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenome, Humanen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney --chemistryen_US
dc.subject.meshKidney Neoplasms --chemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshWilms Tumor --chemistryen_US
dc.titleEstimation of tissue DNA content in Wilm's tumour.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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