Familial aggregation of cancer in patients with bronchogenic carcinoma.
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2000-03-23
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Abstract
History of cancer among first degree relatives was obtained in 124 patients with bronchogenic carcinoma [probands] and 248 controls, and differences in familial aggregation evaluated by calculation of odds ratio [OR] and their 95 percent confidence intervals [95% CI]. Probands were more likely than controls to have relatives with cancers [OR 1.27, 95% CI 0.49-3.10], both among smokers and nonsmokers [OR 1.31, 95% CI 0.27-6.79 and OR 1.21, 95% CI 0.12-6.16 respectively]. Sisters of probands were particularly at a higher risk [OR 8.72, 95% CI 0.85-430.08]. A genetic component, possibly independent of smoking habits, may be important in the causation of lung cancer.
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Gupta D, Aggarwal AN, Vikrant S, Jindal SK. Familial aggregation of cancer in patients with bronchogenic carcinoma. Indian Journal of Cancer. 2000 Mar; 37(1): 43-9