The Impact of Coronavirus Disease 2019 Pandemic on Bronchiolitis (Lower Respiratory Tract Infection) Due to Respiratory Syncytial Virus: A Systematic Review and Meta-Analysis

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dc.contributor.authorSabeena, Sen_US
dc.contributor.authorRavishankar, Nen_US
dc.contributor.authorRobin, Sen_US
dc.contributor.authorPillai, SS.en_US
dc.date.accessioned2023-08-19T04:56:11Z
dc.date.available2023-08-19T04:56:11Z
dc.date.issued2022-06
dc.description.abstractThe coronavirus disease 2019 (COVID‑19) pandemic has changed the epidemiology of respiratory syncytial virus (RSV) infection which accounts for most bronchiolitis and viral pneumonias in infants. This systematic review and meta‑analysis aimed to quantitatively assess the effect of the COVID‑19 pandemic on RSV‑associated bronchiolitis among hospitalized infants. The study protocol was registered in the PROSPERO database (CRD42022314000) and was designed based on Preferred Reporting Items for Systematic Reviews and Meta‑analyses guidelines updated in May 2020. The meta‑analysis component was modified appropriately to synthesize the pooled proportion of infants having RSV‑associated bronchiolitis before the COVID‑19 pandemic in 2019 and during the pandemic with 95% confidence interval (CI). We identified and screened 189 articles and systematically reviewed 50 full texts. Eight qualified studies from Europe and China, including 109,186 symptomatic cases of bronchiolitis before the pandemic in 2019 and 61,982 cases in 2020–2021 were pooled by random‑effects meta‑analysis. The quantitative analysis included laboratory‑confirmed RSV infection in 7691 infants with bronchiolitis reported before the pandemic in 2019. Meanwhile, during the pandemic, 4964 bronchiolitis cases were associated with RSV infection. The pooled proportion of RSV‑associated bronchiolitis cases before the pandemic in 2019 was 16.74% (95% CI 11.73, 22.43%, 95% prediction interval 0.032, 34.16). The pooled proportion of confirmed RSV cases during the pandemic in 2020/2021 was 19.20% (95% CI 12.01, 27.59%, 95% prediction interval 0.046, 42.35). There was an increase in RSV activity after the relaxation of stringent public health measures during the COVID‑19 pandemic.en_US
dc.identifier.affiliationsClinical Virologist, Allure Residency, Lalitpur, Kathmandu, Nepalen_US
dc.identifier.affiliationsAssistant Professor, Department of Biostatistics, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhien_US
dc.identifier.affiliationsResearch Officer, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, Indiaen_US
dc.identifier.affiliationsPaediatric Endocrinology Fellow, Warren Alpert Medical School of Brown University, Providence, RI, USAen_US
dc.identifier.citationSabeena S, Ravishankar N, Robin S, Pillai SS.. The Impact of Coronavirus Disease 2019 Pandemic on Bronchiolitis (Lower Respiratory Tract Infection) Due to Respiratory Syncytial Virus: A Systematic Review and Meta-Analysis. Indian Journal of Public Health. 2023 Jun; 67(2): 284-291en_US
dc.identifier.issn0019-557X
dc.identifier.issn2229-7693
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223926
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume67en_US
dc.source.urihttps://doi.org/10.4103/ijph.ijph_1334_22en_US
dc.subjectBronchiolitisen_US
dc.subjectcoronavirus disease 2019en_US
dc.subjectpandemicen_US
dc.subjectrespiratory syncytial virusen_US
dc.subjectsevere acute respiratory syndrome coronavirus 2en_US
dc.titleThe Impact of Coronavirus Disease 2019 Pandemic on Bronchiolitis (Lower Respiratory Tract Infection) Due to Respiratory Syncytial Virus: A Systematic Review and Meta-Analysisen_US
dc.typeJournal Articleen_US
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