Association of vitamin D deficiency and bone mass with liver and heart iron overload in transfusion dependent thalassemia

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dc.contributor.authorVerma, Anjalien_US
dc.contributor.authorKhanna, Aloken_US
dc.contributor.authorJangra, Babitaen_US
dc.contributor.authorNanda, Sanjiven_US
dc.contributor.authorVerma, Surenderen_US
dc.date.accessioned2020-09-24T07:48:36Z
dc.date.available2020-09-24T07:48:36Z
dc.date.issued2020-07
dc.description.abstractBackground: Transfusion dependent thalassemia patients are reported to have Vitamin D insufficiency/deficiency in many countries. Vitamin D hydroxylation occurs in the liver; whether liver iron overload interferes with this step has not been addressed till date. This study helps to establish an association between liver iron concentration (LIC) and heart iron concentration (MIC) with vitamin D levels and Bone Mass Density in these patients.Methods: A cross sectional study was done by including transfusion dependent Thalassemia patients (TM) if they had an assessment of Liver and cardiac iron done by T2*MRI and bone mineral density by DEXA. Clinical data regarding age, gender, type of iron chelation therapy and laboratory data of S. ferritin and Vitamin D was collected. Data was assessed using appropriate statistical methods.Results: Among 40 TM patients were taken and mean age was 17.6 years. Vitamin D deficiency was identified in 26(65%). 20 out of them had an LIC>7mg/g DW and 6 had MIC>1.65mg/g DW. There was a significant association between LIC>7mg/g and vitamin D level<20 ng/ml and a significant inverse correlation between LIC and vitamin D, suggesting that liver iron overload may indeed affect vitamin D metabolism. Osteopenia was present in 32.5% and osteoporosis was present in 27.5 % of all TM patients. Reduced Bone Mass Density was also found to be linked with iron over load.Conclusions: Regular monitoring of vitamin D levels and supplementation is required in patients with severe liver and heart iron load. More studies are needed to confirm these results.en_US
dc.identifier.affiliationsDepartment of Pediatrics, Narayana Medical College, Chinthareddy Palem, Nellore, Andhra Pradesh, Indiaen_US
dc.identifier.citationVerma Anjali, Khanna Alok, Jangra Babita, Nanda Sanjiv, Verma Surender. Association of vitamin D deficiency and bone mass with liver and heart iron overload in transfusion dependent thalassemia. International Journal of Contemporary Pediatrics. 2020 Jul; 7(7): 1544-1548en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204675
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber7en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20202613en_US
dc.subjectChelationen_US
dc.subjectOsteopeniaen_US
dc.subjectVitamin D insufficiencyen_US
dc.titleAssociation of vitamin D deficiency and bone mass with liver and heart iron overload in transfusion dependent thalassemiaen_US
dc.typeJournal Articleen_US
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