Association of use of statins with progression of diabetic retinopathy: a randomized controlled trial at a tertiary care centre in Southern India

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dc.contributor.authorKhan, SAen_US
dc.contributor.authorAndanappa, Aen_US
dc.contributor.authorKukunoor, HRen_US
dc.contributor.authorNaidu, SVVLen_US
dc.contributor.authorToodi, AR.en_US
dc.date.accessioned2025-08-13T11:44:23Z
dc.date.available2025-08-13T11:44:23Z
dc.date.issued2025-07
dc.description.abstractBackground: Diabetic retinopathy (DR) is a major microvascular complication of type 2 diabetes mellitus (T2DM) and a leading cause of vision impairment globally. Statins, beyond their lipid-lowering and cardiovascular benefits, may offer protective effects against DR by reducing inflammation, stabilizing endothelial function and modulating vascular endothelial growth factor (VEGF) expression. This study aimed to assess the impact of statin therapy on DR severity in patients with T2DM. Methods: A randomized controlled trial was conducted at Government General Hospital, Srikakulam, between April 2024 and February 2025. A total of 120 patients with DR were enrolled and divided into two groups: those receiving statin therapy and those not on statins. DR severity was assessed using fundus examination findings and compared between the two groups. Results: Among the 60 patients on statins, 62.2% had mild non-proliferative diabetic retinopathy (NPDR), while only 3.3% had proliferative DR (PDR) and 1.7% had diabetic macular edema (DME). In contrast, among non-statin users, only 18.2% had mild NPDR, while 29.1% had severe NPDR, 14.5% had PDR and 7.3% had DME. One patient also had vitreous hemorrhage. Conclusions: Statin therapy appears to be associated with milder forms of DR in patients with T2DM. These findings suggest that statins may help slow DR progression, highlighting their potential as an adjunctive therapy for retinal protection in diabetes management.en_US
dc.identifier.affiliationsBharati Vidyapeeth deemed university medical college, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsMysore Medical College and Research Institute, Mysore, Karnataka, Indiaen_US
dc.identifier.affiliationsMaheshwara Medical College and Hospital, Patancheruvu, Telangana, Indiaen_US
dc.identifier.affiliationsAlluri Sita Ramaraju Academy of Medical Sciences, Eluru, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsMediciti Institute of Medical Sciences, Telangana, Indiaen_US
dc.identifier.citationKhan SA, Andanappa A, Kukunoor HR, Naidu SVVL, Toodi AR. . Association of use of statins with progression of diabetic retinopathy: a randomized controlled trial at a tertiary care centre in Southern India . International Journal of Research in Medical Sciences. 2025 Jul; 13(7): 2902-2908en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/254211
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber7en_US
dc.relation.volume13en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20252025en_US
dc.subjectDiabetesen_US
dc.subjectDiabetic retinopathyen_US
dc.subjectLipid lowering therapyen_US
dc.subjectRetinal healthen_US
dc.subjectStatinsen_US
dc.titleAssociation of use of statins with progression of diabetic retinopathy: a randomized controlled trial at a tertiary care centre in Southern Indiaen_US
dc.typeJournal Articleen_US
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